ArticleEuropean geriatric medicine2020
The relationship between malnutrition risk and inflammatory biomarkers in outpatient geriatric population.
Article in European geriatric medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Malnutrition Predicts Adverse Outcomes After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.Anatolian journal of cardiology · 2023Pooled it
- Systemic inflammatory markers as a supplement to nutrition risk screening of ICU patients.Asia Pacific journal of clinical nutrition · 2026Article
- Nutritional needs of non-essential amino acids for intestinal health and growth performance of nursery pigs fed diets without soybean meal.Journal of animal science · 2026Article
- Elevated C-reactive protein-to-albumin ratio as an independent prognostic marker for mortality in sepsis: a multicenter cohort study.Frontiers in cellular and infection microbiology · 2026Article
- Neutrophil-to-lymphocyte ratio as a sex-specific predictor of short-term mortality in hospitalised older adults with COVID-19: a pragmatic biomarker of inflammaging in acute vulnerability.Immunity & ageing : I & A · 2025Article
- Clinical Outcomes Associated with Parenteral Nutrition Caloric Provision in Geriatric Patients with Infectious Colitis.Nutrients · 2025Observational
- Healthcare-Associated Infections (HAIs) in the Elderly: Molecular Mechanisms of Immunosenescence and Clinical, Nutritional and Therapeutic Implications.International journal of molecular sciences · 2025Review
- Article
- Malnutrition and risks of atrial fibrillation recurrence after catheter ablation.Journal of arrhythmia · 2025Article
- Association of Prognostic Nutritional Index with Post-Discharge Bleeding After Percutaneous Coronary Intervention in ACS Patients on DAPT.Therapeutics and clinical risk management · 2025Article
- The Effect of Malnutrition, Inflammatory Biomarkers, and Stress-Induced Hyperglycemia on the Glomerular Filtration Rate in Renal Dysfunction.International journal of general medicine · 2025Article
- Addressing Inflammaging and Disease-Related Malnutrition: Adequacy of Oral Nutritional Supplements in Clinical Care.Nutrients · 2024Review
- MiR-22-3p as a promising predictor of nutritional deficiencies in patients with head and neck cancer subjected to intensity-modulated radiation therapy.Scientific reports · 2024Article
- Advancing the Understanding of Malnutrition in the Elderly Population: Current Insights and Future Directions.Nutrients · 2024Review
- Article
- Nutritional responsiveness affects novel neutrophil parameters and reduces in-hospital mortality and costs in elective cancer oesophagectomy - a single centre, prospective, observational study.Anaesthesiology intensive therapy · 2024Observational
- Prognostic Nutritional Index as a New Prediction Tool for All-Cause Mortality in Patients with Chronic Limb-Threatening Ischemia Undergoing Endovascular Therapy.Sisli Etfal Hastanesi tip bulteni · 2024Article
- Article
- Symptom profiles and related factors among patients with advanced cancer: A latent profile analysis.Asia-Pacific journal of oncology nursing · 2023Article
- C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram.Scientific reports · 2023Article
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5 authors.
Funding
Abstract
purposeMalnutrition is an underestimated, but significant problem among older persons. It is described as a consequence of genetic and environmental factors, lack of physical activity, and co-morbidities. However, a key role of a geriatrician is to further explore the multidimensional complexity of this issue. The aim of this study was to identify the relationship between nutritional status and different factors, particularly focusing on inflammatory biomarkers.
methodsNutritional status was assessed using Mini-Nutritional-Assessment with a score below 24 (out of 30) defined as malnutrition. Different serum biomarkers of inflammation were measured, such as High-Sensitivity-C-Reactive-Protein (hsCRP), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-18(IL-18), osteoprotegerin(OPG), and Soluble-Receptor-For-TNF-alfa(sTNFRII). Medical history, mental status (Mini-Mental-State-Examination, Geriatric-Depression-Scale) and activities of daily living (using Instrumental-Activities-of-Daily-Living-Scale) were used in the evaluation. The relationship between nutritional status and the factors listed was assessed.
resultsThe mean age of 76 examined persons (40.8% female) from the outpatient clinic was 71 years. Malnutrition risk was recognized in 29%. The following factors significant in univariate regression were used in stepwise regression analysis: age, sex, mental status (MMSE, GDS), valve disease, number of diseases, IADL. Stepwise regression revealed that the risk of malnutrition was increased by the presence of valve disease, number of diseases, and female sex. Factors that increased the risk of malnutrition were: logsTNFRII (OR = 3.09; 95% CI 1.07-8.96), IL-8 (OR = 1.09; 95% CI 1.00-1.18), and OPG (OR = 1.27; 95% CI 1.02-1.57). Risk of malnutrition was negatively associated with Il-18(OR = 0.995; 95% CI 0.991-0.999).
conclusionsChronic inflammation and immunologic process are likely contributors to the complex etiopathogenesis of malnutrition in older persons.
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