Evidence map›Paper›PMID 32297178›Full record

ArticleMolecular and cellular biochemistry2020

Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis.

Chen Wang, Jinping Xu, Dexiao Yuan, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chen WangInstitute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai, 20032, China.
Jinping XuInstitute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai, 20032, China.
Dexiao YuanInstitute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai, 20032, China.
Yang BaiInstitute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai, 20032, China.
Yan PanInstitute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai, 20032, China.
Jianghong ZhangInstitute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai, 20032, China.
Chunlin ShaoInstitute of Radiation Medicine, Fudan University, No. 2094 Xie-Tu Road, Shanghai, 20032, China. clshao@shmu.edu.cn.
Fudan University · CN

Funding

National Nature Science Foundation of China Grant Nos. 31770910, 31570850, 81672985 and 11775052the National Key R&D Program of China No. 2017YFC0108604
6 · The paper itself

Abstract

Lung cancer has been recognized as the leading cause of cancer-related death worldwide. Despite the improvements of treatment, the distant metastasis and recurrence of lung cancer caused by therapy resistance is the biggest challenge in clinical management. Extracellular vesicles named exosomes play crucial roles in intercellular communication as signaling mediators and are involved in tumor development. In this study, we isolated exosomes from irradiated lung cancer cells and co-cultured the exosomes with other lung cancer cells. It was found that cellular growth and motility of recipient cells were facilitated. High-throughput LC-MS/MS assay of exosomal proteins and Gene Ontology enrichment analyses indicated that the metabolic enzymes ALDOA and ALDH3A1 had potential contribution in exosome-enhanced motility of recipient cells, and clinical survival analysis demonstrated the close correlations between ALDOA or ALDH3A1 expression and poor prognosis of lung cancer patients. After co-culturing with exosomes derived from irradiated cancer cells, the expressions of these metabolic enzymes were elevated and the glycolytic activity was promoted in recipient cancer cells. In conclusion, our data suggested that exosomes from irradiated lung cancer cells regulated the motility of recipient cells by accelerating glycolytic process, where exosomal ALDOA and ALDH3A1 proteins were important signaling factors.

Indexed as

GlycolysisAldehyde DehydrogenaseCell CommunicationCell Line, TumorCell MovementCell ProliferationChromatography, LiquidCoculture TechniquesExosomesFructose-Bisphosphate AldolaseGene Expression Regulation, NeoplasticGene OntologyHumansLung NeoplasmsMicroscopy, Electron, TransmissionNeoplasm Recurrence, LocalAldehyde DehydrogenaseALDH3A1 protein, humanALDOA protein, humanFructose-Bisphosphate AldolaseCell motilityExosomesGlycolytic proteinsLung cancer cellsRadiation

Identifiers

PMID32297178
OpenAlexW3016506004

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.