Trial reportSleep & breathing = Schlaf & Atmung2021
Effect of CPAP therapy on nocturnal blood pressure fluctuations, nocturnal blood pressure, and arterial stiffness in patients with coexisting cardiovascular diseases and obstructive sleep apnea.
Trial report in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- High-Intensity Atorvastatin and 24-Hour Blood Pressure in Obstructive Sleep Apnea: A Randomized, -Double-Blind, Placebo-Controlled Pilot Study.American journal of hypertension · 2026Trial
- Nocturnal blood pressure and nocturnal blood pressure fluctuations: the effect of short-term CPAP therapy and their association with the severity of obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- The effect of PAP on UACR and metabolic indexes in patients with MS and OSAHS.Sleep & breathing = Schlaf & Atmung · 2024Article
- Hypoxia-Induced Insulin Resistance Mediates the Elevated Cardiovascular Risk in Patients with Obstructive Sleep Apnea: A Comprehensive Review.Reviews in cardiovascular medicine · 2024Review
- Management of nocturnal hypertension: An expert consensus document from Chinese Hypertension League.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- New perspective on exploring the predictive factors of blood pressure reduction during CPAP treatment in people with severe OSA and hypertension: a prospective observational study.BMJ open respiratory research · 2023Observational
- Association between Previous CPAP and Comorbidities at Diagnosis of Obesity-Hypoventilation Syndrome Associated with Obstructive Sleep Apnea: A Comparative Retrospective Observational Study.Journal of clinical medicine · 2023Article
- The long-term impact of expansion sphincter pharyngoplasty treatment on blood pressure control and health-related quality of life in patients with obstructive sleep apnea and hypertension.Sleep & breathing = Schlaf & Atmung · 2021Article
- Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate-Severe OSA and Metabolic Syndrome-A Pilot Study.Journal of clinical medicine · 2021Article
- Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community-Based Cohort Studies.Journal of the American Heart Association · 2021Observational
- Obstructive Sleep Apnea as a Cardiovascular Risk Factor-Beyond CPAP.The Canadian journal of cardiology · 2021Review
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObstructive sleep apnea (OSA) can induce dramatic nocturnal blood pressure fluctuations (NBPFs) and can be associated with nocturnal hypertension and arterial stiffness. We investigated the effect of short- and long-term continuous positive airway pressure (CPAP) therapy on NBPFs, nocturnal blood pressure (BP), and arterial stiffness in patients with coexisting cardiovascular diseases (CVD) and OSA (CVD/OSA).
methodsOf 86 patients with CVD, 58 also had OSA, while 28 without OSA served as controls. Nighttime BP was measured continuously using pulse transit time (PTT) and arterial stiffness was measured with pulse wave velocity (PWV). A NBPF was defined as systolic BP elevation > 12 mmHg in a 30 s interval of sleep. All measurements were conducted at baseline, after the first night of CPAP, and after 6 months of CPAP therapy.
resultsIn CVD/OSA patients, we observed significantly more frequent NBPFs (p < 0.001) compared with controls. CPAP therapy decreased the frequency of NBPFs (p < 0.001), the maximum systolic BP by 9 mmHg (p = 0.021), and PWV (p < 0.001) even after the first night. After long-term CPAP therapy, there was an additional decrease in average nocturnal systolic BP by 10 mmHg (p = 0.039).
conclusionsOur findings demonstrate that CPAP therapy reduces NBPFs, nocturnal BP, and arterial stiffness in CVD/OSA patients. This effect was demonstrable after the first night of CPAP and grew more robust after 6 months of CPAP therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.