ArticleLa Radiologia medica2021
Cone-beam computed tomography for organ motion evaluation in locally advanced rectal cancer patients.
Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- Factors influencing dose delivery in rectal cancer radiotherapy using CBCT-guided intensity modulated techniques.Radiation and environmental biophysics · 2026Article
- Setup and target volume shape variation in rectal cancer radiotherapy: a systematic literature review.Technical innovations & patient support in radiation oncology · 2026Review
- Evaluating primary tumor position variation for rectal cancer patients treated with long course radiotherapy.Physics in medicine and biology · 2025Article
- Investigation of changes in planning target volume and regression probability of rectal boost using in-silico cone-beam computed tomography-guided online-adaptive radiotherapy.Physics and imaging in radiation oncology · 2025Article
- Qualitative and quantitative evaluation of the role of CBCT in rectal cancer radiotherapy.La Radiologia medica · 2025Review
- Unsupervised Deep Learning for Synthetic CT Generation from CBCT Images for Proton and Carbon Ion Therapy for Paediatric Patients.Sensors (Basel, Switzerland) · 2024Article
- An Updated Review on Imaging and Staging of Anal Cancer-Not Just Rectal Cancer.Tomography (Ann Arbor, Mich.) · 2023Review
- Mesorectal motion evaluation in rectal cancer MR-guided radiotherapy: an exploratory study to quantify treatment margins.Radiation oncology (London, England) · 2023Article
- Integration between Novel Imaging Technologies and Modern Radiotherapy Techniques: How the Eye Drove the Chisel.Cancers · 2022Review
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- The Role of Magnetic Resonance Enterography in Crohn's Disease: A Review of Recent Literature.Diagnostics (Basel, Switzerland) · 2022Review
- Radiomics and Machine Learning Analysis Based on Magnetic Resonance Imaging in the Assessment of Colorectal Liver Metastases Growth Pattern.Diagnostics (Basel, Switzerland) · 2022Article
- Radiomics as a New Frontier of Imaging for Cancer Prognosis: A Narrative Review.Diagnostics (Basel, Switzerland) · 2021Review
- DWI-MR and PET-CT Functional Imaging for Boost Tumor Volume Delineation in Neoadjuvant Rectal Cancer Treatment.In vivo (Athens, Greece)Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDue to a reported dose-response relationship in rectal cancer radiotherapy, a greater interest in dose intensification on small boost volume arises. Considering the need of an appropriate target movements evaluation, this retrospective study aimed to use cone-beam computed tomography (CBCT) for GTV and mesorectum organ motion (OM) evaluation, in locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemo-radiotherapy, in prone and supine position.
methodsThirty-two LARC patients were analyzed. GTV and mesorectum were delineated on MRI co-registrated with CT simulation. GTV and mesorectum OM was estimated on all CBCTs, performed during treatment, co-registrated with CT simulation. OM evaluation was obtained, as mean shift in left and right (L-R), postero-anterior (P-A) and cranio-caudal (Cr-C) directions. Volumes variability was calculated by DICE index.
resultsA total of 296 CBCTs were analyzed. Mean shifts of the GTV and mesorectum in prone position were - 0.16 cm and 0.15 cm in L-R direction, 0.28 cm and - 0.40 cm in P-A direction, and 0.14 cm and - 0.21 cm, in Cr-C direction; for supine position the mean shifts of the GTV were - 0.10 cm and 0.17 cm in R-L direction, 0.26 cm and - 0.23 cm in A-P direction, 0.09 cm and - 0.11 cm in Cr-C direction. Mean DICE index for GTV and mesorectum was 0.74 and 0.86, in prone position, and 0.78 and 0.89 in supine position, respectively.
conclusionGTV and mesorectum OM was less than 4 mm in all directions in both positions, with a 1 mm less deviation in supine position. CBCTs resulted effective for OM assessment, and it could be an appropriate method for the implementation on an intensification treatment.
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