ArticlePediatric nephrology (Berlin, Germany)2020
An evaluation of preterm kidney size and function over the first two years of life.
Article in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Pooled it
- From survival to surveillance: the long-term kidney legacy of preterm birth.Pediatric nephrology (Berlin, Germany) · 2026Article
- Renal function impairment in children with intestinal failure receiving parenteral nutrition: A descriptive cohort study.JPEN. Journal of parenteral and enteral nutrition · 2026Observational
- A Model to Define Reference Ultrasound Parameters for Early Assessment of Nephron Endowment in Extremely Low Birth Weight Preterm Infants.Children (Basel, Switzerland) · 2026Article
- Maternal and fetal determinants on kidney size in early childhood: insights from a New York City cohort.BMC nephrology · 2026Article
- Renal consequences of prematurity and utility of serum uromodulin as a marker of kidney growth- a cross sectional single centre study.BMC nephrology · 2026Article
- Physiologically Based Pharmacokinetics Modeling in the Neonatal Population-Current Advances, Challenges, and Opportunities.Pharmaceutics · 2023Review
- Developmental Pharmacokinetics of Antibiotics Used in Neonatal ICU: Focus on Preterm Infants.Biomedicines · 2023Review
- Preterm Birth, Kidney Function and Cardiovascular Disease in Children and Adolescents.Children (Basel, Switzerland) · 2022Review
- Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm.Clinical kidney journal · 2022Article
- Neonatal acute kidney injury: a case-based approach.Pediatric nephrology (Berlin, Germany) · 2021Review
- Renal deficit and associated factors in children born with low birth weight.Jornal brasileiro de nefrologiaArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe carried out a study to determine the impact of prematurity on kidney development in the first 2 years of life.
methodsIn this prospective study, extremely preterm neonates (gestation < 28 weeks) were recruited and underwent assessments at 6, 12, and 24 months of age. A cohort of neonates born term were also recruited and followed up for 24 months. The primary outcomes measured in this study were total kidney volume (TKV) and estimated glomerular filtration rate (eGFR); albuminuria and blood pressure measurements (all provided as mean (standard deviation)) were the secondary outcomes.
resultsFifty-three premature and 31 term neonates (control) were recruited. At the age of 24 months (corrected age), infants born preterm had significantly smaller TKV (56.1 (9.4) vs. 64.8 (10.2) mL; P = 0.006). There was no difference in eGFR. These preterm infants were smaller (11.25 (1.53) vs. 12.9 (1.8) kg; P = 0.002) and shorter (83.8 (3.0) vs. 86.3 (3.4) cm; P = 0.02) when compared with the control group. At 6, 12, and 18 months respectively, preterm infants had, relative to their height, significantly smaller kidney volumes (0.54 (0.1) vs. 0.59 (0.1) mL/cm, P = 0.05; 0.61 (0.1) vs.0.71 (0.1) mL/cm, P = 0.003; and 0.67 (0.1) vs.0.76 (0.1) mL/cm, P = 0.006).
conclusionsRelative to body length, TKV in premature infants is smaller. Since length reflects adult body proportions more accurately than BSA, TKV to height ratio may be a more important measure in the child. Despite smaller TKV (and therefore fewer nephrons), infants born prematurely achieve similar eGFRs in the first 24 months of life, probably due to single-nephron hyperfiltration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.