Evidence map›Paper›PMID 32296971›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2021

Left atrial appendage closure in patients with chronic kidney disease: results from the German multicentre LAARGE registry.

Christian Fastner, Johannes Brachmann, Thorsten Lewalter, Uwe Zeymer, Horst Sievert, Martin Borggrefe, Christoph A Nienaber, Christian Weiß, Sven T Pleger, Hüseyin Ince and 7 more

Abstract readMulticenter Study
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Left atrial appendage occlusion in patients with end-stage renal disease: an individual patient-level meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Pooled it
  2. Transcatheter left atrial appendage occlusion in patients with chronic kidney disease: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
    Pooled it
  3. Risk factors, clinical implications, and management of peridevice leak following left atrial appendage closure: A systematic review.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024
    Pooled it
  4. Pooled it
  5. Review
  6. Practical guide on left atrial appendage closure for the non-implanting physician: an international consensus paper.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  7. Article
  8. Association of atrial myopathy in mitral valve disease on safety outcomes in left atrial appendage closure.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Article
  9. Review
  10. Article
  11. Impact of atrial fibrillation pattern on outcomes after left atrial appendage closure: lessons from the prospective LAARGE registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2022
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Christian FastnerFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg/Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Johannes BrachmannDepartment of Cardiology, Angiology, and Pneumology, Second Medical Clinic, Coburg Hospital, Coburg, Germany.
Thorsten LewalterDepartment of Medicine, Cardiology, and Intensive Care, Hospital Munich-Thalkirchen, Munich, Germany.
Uwe ZeymerKlinikum Ludwigshafen, Ludwigshafen am Rhein, Germany.
Horst SievertCardioVascular Center (CVC) Frankfurt, Frankfurt, Germany.
Martin BorggrefeFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg/Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Christoph A NienaberCardiology and Aortic Center, Royal Brompton and Harefield NHS Foundation, Trust at Imperial College, London, UK.
Christian WeißDepartment of Cardiology, Klinikum Lüneburg, Lüneburg, Germany.
Sven T PlegerDepartment of Internal Medicine III, Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, Heidelberg, Germany.
Hüseyin InceDepartment of Cardiology, Rostock University Medical Center, Rostock, Germany.
Jens MaierMedical Department I, SLK-Kliniken Heilbronn GmbH, Klinikum am Gesundbrunnen, Heilbronn, Germany.
Stephan AchenbachDepartment of Medicine, University of Erlangen, Erlangen, Germany.
Holger H SiguschClinic for Internal Medicine I, Heinrich-Braun-Klinikum Zwickau gGmbH, Zwickau, Deutschland.
Matthias HochadelStiftung Institut für Herzinfarktforschung, Ludwigshafen am Rhein, Germany.
Steffen SchneiderStiftung Institut für Herzinfarktforschung, Ludwigshafen am Rhein, Germany.
Jochen SengesStiftung Institut für Herzinfarktforschung, Ludwigshafen am Rhein, Germany.
Ibrahim AkinFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg/Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. ibrahim.akin@umm.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesChronic kidney disease (CKD) is associated with an increased complication rate after cardiac interventions. Although CKD has a high prevalence among atrial fibrillation patients, the impact of CKD on periprocedural complications and the outcome after an interventional left atrial appendage closure (LAAC) is unclear. The present study, therefore, aimed to investigate whether CKD influences the procedure's effectiveness and safety.

methodsLAARGE is a prospective, non-randomised registry. LAAC was conducted with different standard commercial devices, and the follow-up period was one year. CKD was defined by an eGFR < 60 mL/min/1.73 m

resultsTwo hundred ninety-nine of 623 patients (48.0%) revealed a CKD. The prevalence of cardiovascular comorbidity, CHA

conclusionsDespite an increased cardiovascular risk profile of CKD patients, device implantation was safe, and LAAC was associated with effective stroke prevention across all CKD stages.

Indexed as

RegistriesSeptal Occluder DeviceAgedAged, 80 and overAtrial AppendageAtrial FibrillationCardiac Surgical ProceduresFemaleFollow-Up StudiesGermanyGlomerular Filtration RateHumansMaleProspective StudiesRenal Insufficiency, ChronicTreatment OutcomeAtrial fibrillationChronic kidney diseaseLAARGELeft atrial appendageLeft atrial appendage closure

Identifiers

PMID32296971
PMCPMC7806558

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.