Evidence map›Paper›PMID 32296927›Full record

ReviewMolecular genetics and genomics : MGG2020

Pioneer factors and their in vitro identification methods.

Xinyang Yu, Michael J Buck

Abstract readReview
In one paragraph

Review in Molecular genetics and genomics : MGG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xinyang YuZhuhai Precision Medical Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, 519000, Guangdong, P.R. China. xyu26@buffalo.edu.
Michael J BuckDepartment of Biochemistry, New York State Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY, 14203, USA. mjbuck@buffalo.edu.

Funding

A high-throughput, comprehensive, and quantitative approach for measuring nucleosome-protein bindingR01GM132199 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BUCK, MICHAEL JOSEPH · 2019 to 2022
$1.4M
National Key Research and Development Program of China 2017YFA0205203National Natural Science Foundation of China 81771957National Natural Science Foundation of China 81901857NIGMS NIH HHS R01 GM132199
6 · The paper itself

Abstract

Pioneer transcription factors are a special group of transcription factors that can interact with nucleosomal DNA and initiate regulatory events. Their binding to regulatory regions is the first event in gene activation and can occur in silent or heterochromatin regions. Several research groups have endeavored to define pioneer factors and study their binding characteristics using various techniques. In this review, we describe the in vitro methods used to define and characterize pioneer factors, paying particular attention to differences in methodologies and how these differences can affect results.

Indexed as

DNADNA-Binding ProteinsGATA4 Transcription FactorGene Expression Regulation, DevelopmentalHepatocyte Nuclear Factor 3-alphaHumansMolecular BiologyNucleosomesProtein BindingTranscription FactorsDNADNA-Binding ProteinsFOXA1 protein, humanGATA4 protein, humanGATA4 Transcription FactorHepatocyte Nuclear Factor 3-alphaNucleosomesTranscription FactorsBinding assaysNucleosomesPioneer factorsTranscription factors

Identifiers

PMID32296927
PMCPMC7405852

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.