ArticleCurrent microbiology2020
Characterization of Gut Microbiota in Hospitalized Patients with Clostridioides difficile Infection.
Article in Current microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Characterization of the Gut Microbiome of Patients withPathogens (Basel, Switzerland) · 2026Article
- Rational Design of Live Biotherapeutic Products for the Prevention of Clostridioides difficile Infection.The Journal of infectious diseases · 2025Article
- Health Effects and Therapeutic Potential of the Gut MicrobeNutrients · 2025Review
- NKp46Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Impact of Selenium Nanoparticle-Enriched Lactobacilli Feeding Against Escherichia coli O157:H7 Infection of BALB/c Mice.Probiotics and antimicrobial proteins · 2024Article
- Rational Design of Live Biotherapeutic Products for the Prevention ofbioRxiv : the preprint server for biology · 2024Article
- Gut Microbiota Composition andGut microbes reports · 2024Article
- Gut microbiome changes in mouse, Mongolian gerbil, and hamster models followingFrontiers in microbiology · 2024Article
- Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota.Microorganisms · 2023Review
- Review
- Case Report: Oral and fecal microbiota in a super-donor: the healthy microbiota paradigm for fecal transplantation.Frontiers in microbiomes · 2023Article
- Characterization of the gut microbiome of patients withFrontiers in cellular and infection microbiology · 2023Article
- Disease-associated dysbiosis and potential therapeutic role of Akkermansia muciniphila, a mucus degrading bacteria of gut microbiome.Folia microbiologica · 2022Review
- Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges.NPJ biofilms and microbiomes · 2022Review
- Gut Microbiota Composition Associated withPathogens (Basel, Switzerland) · 2022Review
- Antibiotic and antifungal use in pediatric leukemia and lymphoma patients are associated with increasing opportunistic pathogens and decreasing bacteria responsible for activities that enhance colonic defense.Frontiers in cellular and infection microbiology · 2022Article
- Review
- An Osmotic Laxative Renders Mice Susceptible to Prolonged Clostridioides difficile Colonization and Hinders Clearance.mSphere · 2021Article
- Gut Dysbiosis andFrontiers in microbiology · 2021Review
- Probiotic Yeasts andFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridioides difficile infection (CDI) is one of the most common causes of nosocomial diarrhea in developed countries and the main cause in healthcare settings. This case-control study was designed to evaluate the composition of the gut microbiota dominant bacterial groups in patients with CDI compared to the healthy control subjects. A total of 100 adult subjects involving 50 inpatients with CDI and 50 healthy persons were enrolled in the study. C. difficile isolates were characterized according to the anaerobic culture and presence of toxin genes with multiplex PCR. An ecological analysis was performed real-time quantitative PCR for bacterial elements. The abundances of Enterococcus spp., Lactobacillus spp., Escherichia coli, C. difficile, and Akkermansia muciniphila were higher in group CDI compared with group HC (P < 0.05). The abundances of Bacteroides spp., Bifidobacterium spp., and Faecalibacterium prausnitzii were lower in group CDI than in group HC (P < 0.05). No significant difference was observed in the copy number of Prevotella genus between the CDI and HC subjects (P-value = 0.087). We observed that economic status and income levels were reduced at patients with CDI, however, there was no significant difference between CDI and HC group results and other variables, such as age, BMI, and educational level. These findings showed a reduction in butyrate-producing bacteria and increase in lactic acid-producing bacteria was seen in CDI status. Overrepresentation of Akkermansia may be a predictive marker for the development of nosocomial diarrhea can result in a worse CDI prognosis.
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Registered trials
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