ArticleRegenerative biomaterials2020
Human adipose-derived mesenchymal stem cells accelerate decellularized neobladder regeneration.
Article in Regenerative biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- A Triple-Layered Composite Scaffold of Silk Fibroin and Decellularized Amniotic Membrane for Bladder Tissue Engineering.Macromolecular bioscience · 2025Article
- Stem cell therapy for bladder regeneration: A comprehensive systematic review.Regenerative therapy · 2025Review
- The Effect of Adipose-Derived Stem Cell (ADSC)-Exos on the Healing of Autologous Skin Grafts in Miniature Pigs.International journal of molecular sciences · 2025Article
- 75% ethanol disinfection preserves biocompatibility and mechanical properties of swim bladder for cardiovascular applications.American journal of translational research · 2025Article
- Transcriptome and Proteome Analysis Identify Decorin as a Principal Antifibrotic Component Trapping TGF-Stem cells international · 2025Article
- A bilayer bioengineered patch with sequential dual-growth factor release to promote vascularization in bladder reconstruction.Regenerative biomaterials · 2024Article
- [Effects and mechanism of annexin A1-overexpressing human adipose-derived mesenchymal stem cells in the treatment of mice with acute respiratory distress syndrome].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Research progress of biomaterials and innovative technologies in urinary tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications.Materials today. Bio · 2022Review
- Therapies Based on Adipose-Derived Stem Cells for Lower Urinary Tract Dysfunction: A Narrative Review.Pharmaceutics · 2022Review
- [Effects of exosomes from human adipose-derived mesenchymal stem cells on pulmonary vascular endothelial cells injury in septic mice and its mechanism].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Prx1 + and Hic1+ Mesenchymal Progenitors Are Present Within the Epidural Fat and Dura Mater and Participate in Dural Injury Repair.Stem cells translational medicine · 2022Article
- 3D Bioprinting of an In Vitro Model of a Biomimetic Urinary Bladder with a Contract-Release System.Micromachines · 2022Article
- Design strategies for composite matrix and multifunctional polymeric scaffolds with enhanced bioactivity for bone tissue engineering.Frontiers in chemistry · 2022Review
- Considerations for the clinical use of stem cells in genitourinary regenerative medicine.World journal of stem cells · 2021Review
- Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal.Bioactive materials · 2021Review
- Adipose tissue-derived stem cells in breast reconstruction: a brief review on biology and translation.Stem cell research & therapy · 2021Review
- Cell-Seeded Acellular Artery for Reconstruction of Long Urethral Defects in a Canine Model.Stem cells international · 2021Article
- Injectable Gel Form of a Decellularized Bladder Induces Adipose-Derived Stem Cell Differentiation into Smooth Muscle Cells In Vitro.International journal of molecular sciences · 2020Article
- Characterization of Crystalline Phase of TiOMaterials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decellularized natural bladder matrices (neobladders) represent an exciting means to regenerate the bladder following bladder cancer-associated cystectomy. In this study, we compare the evolution of decellularized matrices with recellularized matrices by seeding it with human adipose-derived mesenchymal stem cells (ADSC) after implantation following partial cystectomy in rats. We discovered significant anatomical differences since 10 days after neobladder implantation with the ADSC-containing matrices promoting a significant recovery of mature p63- and cytokeratin 7-positive urothelium. We also discovered significantly induced expression of the vimentin mesoderm marker in the submucosal layer in ADSC-seeded matrices. Interestingly, we found a higher expression of smooth muscle actin in transversal and longitudinal smooth muscle layers with ADSC-seeded matrices. Furthermore, ADSC also showed increased vascularization and nerve innervation of the neobladder as determined by the distribution of CD31 and S100β reactivity, respectively. We believe that ADSC and their paracrine-acting pro-regenerative secretome within decellularized matrices represent an efficient bladder substitution strategy; however, we require a fuller understanding of the mechanisms involved before clinical studies can begin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.