Evidence map›Paper›PMID 32296428›Full record

ArticleFrontiers in immunology2020

CD3ε

Adeline N Boettcher, A Giselle Cino-Ozuna, Yash Solanki, Jayne E Wiarda, Ellie Putz, Jeana L Owens, Sara A Crane, Amanda P Ahrens, Crystal L Loving, Joan E Cunnick and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Swine models for translational oncological research: an evolving landscape and regulatory considerations.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Review
  4. Allogeneic and xenogeneic lymphoid reconstitution in aFrontiers in veterinary science · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Adeline N BoettcherDepartment of Animal Science, Iowa State University, Ames, IA, United States.
A Giselle Cino-OzunaVeterinary Diagnostic Laboratory, Kansas State University, Manhattan, KS, United States.
Yash SolankiDepartment of Animal Science, Iowa State University, Ames, IA, United States.
Jayne E WiardaFood Safety and Enteric Pathogen Unit, National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA, United States.
Ellie PutzDepartment of Animal Science, Iowa State University, Ames, IA, United States.
Jeana L OwensVeterinary Diagnostic Laboratory, Kansas State University, Manhattan, KS, United States.
Sara A CraneDepartment of Animal Science, Iowa State University, Ames, IA, United States.
Amanda P AhrensLaboratory Animal Research, Iowa State University, Ames, IA, United States.
Crystal L LovingFood Safety and Enteric Pathogen Unit, National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, IA, United States.
Joan E CunnickDepartment of Animal Science, Iowa State University, Ames, IA, United States.
Raymond R R RowlandDiagnostic Medicine and Pathobiology Department, Kansas State University, Manhattan, KS, United States.
Sara E CharleyDepartment of Animal Science, Iowa State University, Ames, IA, United States.
Jack C M DekkersDepartment of Animal Science, Iowa State University, Ames, IA, United States.
Christopher K TuggleDepartment of Animal Science, Iowa State University, Ames, IA, United States.
Iowa State University · USKansas State University · USNational Animal Disease Center · US

Funding

Expanding the Utility of Severe Combined Immuno-Deficient (SCID) Pig ModelsR24OD019813 · OD · IOWA STATE UNIVERSITY · PI TUGGLE, CHRISTOPHER · 2015 to 2019
$2.7M
NIH HHS R24 OD019813
6 · The paper itself

Abstract

Severe combined immunodeficiency (SCID) is described as the lack of functional T and B cells. In some cases, mutant genes encoding proteins involved in the process of VDJ recombination retain partial activity and are classified as hypomorphs. Hypomorphic activity in the products from these genes can function in the development of T and B cells and is referred to as a leaky phenotype in patients and animals diagnosed with SCID. We previously described two natural, single nucleotide variants in

Indexed as

Disease Models, AnimalAnimalsCD3 ComplexDNA-Binding ProteinsEndonucleasesSevere Combined ImmunodeficiencySwineT-Lymphocyte SubsetsCD3 ComplexDNA-Binding ProteinsEndonucleasesartemisSCIDsevere combined immunodeficiencyswineT cell

Identifiers

PMID32296428
PMCPMC7136459
OpenAlexW3014654051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.