Evidence map›Paper›PMID 32296389›Full record

ArticleFrontiers in endocrinology2020

Expression Profiling, Downstream Signaling, and Inter-subunit Interactions of GPA2/GPB5 in the Adult Mosquito

David A Rocco, Jean-Paul V Paluzzi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David A RoccoLaboratory of Integrative Vector Neuroendocrinology, Department of Biology, York University, Toronto, ON, Canada.
Jean-Paul V PaluzziLaboratory of Integrative Vector Neuroendocrinology, Department of Biology, York University, Toronto, ON, Canada.
York University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GPA2/GPB5 and its receptor constitute a glycoprotein hormone-signaling system native to the genomes of most vertebrate and invertebrate organisms. Unlike the well-studied gonadotropins and thyrotropin, the exact function of GPA2/GPB5 remains elusive, and whether it elicits its functions as heterodimers, homodimers or as independent monomers remains unclear. Here, the glycoprotein hormone signaling system was investigated in adult mosquitoes, where GPA2 and GPB5 subunit expression was mapped and modes of its signaling were characterized. In adult

Indexed as

AedesAmino Acid SequenceAnimalsGene Expression ProfilingGlycoproteinsHEK293 CellsHumansProtein BindingProtein Interaction MapsProtein MultimerizationSignal TransductionGlycoproteinsthyrostimulinglycoprotein hormoneGPA2/GPB5heterodimerhomodimerleucine-rich repeat-containing G protein coupled-receptor 1mosquitothyrostimulin

Identifiers

PMID32296389
PMCPMC7137729
OpenAlexW3014627384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.