Evidence map›Paper›PMID 32296333›Full record

SynthesisFrontiers in pharmacology2020

Patient-Related Risk Factors for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review.

Abu Saleh Mohammad Mosa, A Mosharraf Hossain, Beau James Lavoie, Illhoi Yoo

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Prevalence of antibody drug conjugated-induced nausea and vomiting (ADCINV) in patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  7. Multi-day vs single-day dexamethasone for the prophylaxis of chemotherapy-induced nausea and vomiting: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  16. Auriculotherapy and acupuncture treatments for chemotherapy-induced nausea and vomiting: a multicenter clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abu Saleh Mohammad MosaDepartment of Health Management and Informatics, School of Medicine, University of Missouri, Columbia, MO, United States.
A Mosharraf HossainDivision of Hematology and Medical Oncology, School of Medicine, University of Missouri, Columbia, MO, United States.
Beau James LavoieDepartment of Health Management and Informatics, School of Medicine, University of Missouri, Columbia, MO, United States.
Illhoi YooDepartment of Health Management and Informatics, School of Medicine, University of Missouri, Columbia, MO, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have reported that patient-related factors significantly impact the risk of Chemotherapy-Induced Nausea and Vomiting (CINV). The objective of this study was to analyze those risk factors of CINV through a systematic literature review.

methodsWe searched MEDLINE to identify articles that addressed patient-related risk factors of CINV through clinical studies.

resultsA total of 49 articles were selected for this study. A total of 28 patient-related risk-factors that significantly impact the risk of CINV were documented. Three factors are demographically related, 17 factors are intrinsic in nature and innate to patient's physiology or influenced by physiology, and eight factors are extrinsic in nature. At least five studies identified seven risk factors with notable summary odds ratio: history of nausea/vomiting (odds ratio: 3.13, 95% CI 2.40-4.07, p < 0.05), female sex (odds ratio: 2.79, 95% CI 2.26-3.44, p < 0.05), expectancy of CINV (odds ratio: 2.61, 95%CI 1.69-4.02, p < 0.05), younger age (odds ratio: 2.59, 95% CI 2.18-3.07, p < 0.05), anxiety (odds ratio: 2.57, 95% CI 1.94-3.40, p < 0.05), history of morning sickness (odds ratio: 1.97, 95% CI 1.46-2.65, p < 0.05), and low alcohol intake (odds ratio: 1.94, 95% CI 1.68-2.24, p < 0.05).

conclusionsOncologists can use these factors prior to the initiation of a chemotherapy regimen to identify patients at risk for CINV, in order to focus on more comprehensive antiemetic treatment options for those high-risk patients. This may enable better outcomes and avoid complications.

Indexed as

cancerChemotherapy-Induced Nausea and Vomiting (CINV)emetogenicitypatient-related risk factorssystematic review

Identifiers

PMID32296333
PMCPMC7138899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.