ArticleFrontiers in neuroscience2020
fMRI-Targeted High-Angular Resolution Diffusion MR Tractography to Identify Functional Language Tracts in Healthy Controls and Glioma Patients.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review.Journal of neuro-oncology · 2023Pooled it
- Comparison between inferior frontal gyrus intrinsic connectivity network and verb-generation task fMRI network for presurgical language mapping in healthy controls and in glioma patients.Brain imaging and behavior · 2022Pooled it
- Passive intraoperative motor fMRI under general anesthesia during open-craniotomy glioma surgery: a prospective technical feasibility study.Brain & spine · 2026Article
- Post-surgery Insights: Exploring Neurocognitive Enigma in Low-grade Glioma Involving the Superior Longitudinal Fasciculus.Annals of neurosciences · 2025Article
- An enhanced CNN-Bi-transformer based framework for detection of neurological illnesses through neurocardiac data fusion.Scientific reports · 2025Article
- From classic models to new pathways: unraveling the anatomy and function of the inferior fronto-occipital fasciculus in language processing.Frontiers in psychology · 2025Article
- Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging-Tractography in Resective Brain Surgery: Lesion Coverage Strategies and Patient Outcomes.Brain sciences · 2023Article
- Advanced pediatric neuroimaging.Pediatric radiology · 2023Review
- Karawun: a software package for assisting evaluation of advances in multimodal imaging for neurosurgical planning and intraoperative neuronavigation.International journal of computer assisted radiology and surgery · 2023Article
- A narrative review of the anatomy and function of the white matter tracts in language production and comprehension.Frontiers in human neuroscience · 2023Review
- Involvement of White Matter Language Tracts in Glioma: Clinical Implications, Operative Management, and Functional Recovery After Injury.Frontiers in neuroscience · 2022Review
- Review
- Along-tract statistics of neurite orientation dispersion and density imaging diffusion metrics to enhance MR tractography quantitative analysis in healthy controls and in patients with brain tumors.Human brain mapping · 2021Article
- Advancements in Neuroimaging to Unravel Biological and Molecular Features of Brain Tumors.Cancers · 2021Review
- Benefit of Action Naming Over Object Naming for Visualization of Subcortical Language Pathways in Navigated Transcranial Magnetic Stimulation-Based Diffusion Tensor Imaging-Fiber Tracking.Frontiers in human neuroscience · 2021Article
- Risk Assessment by Pre-surgical Tractography in Left Hemisphere Low-Grade Gliomas.Frontiers in neurology · 2021Article
- A Practical Approach to Imaging of the Supplementary Motor Area and Its Subcortical Connections.Current neurology and neuroscience reports · 2020Review
- Disrupted Amygdala Connectivity Is Associated With Elevated Anxiety in Sensorineural Hearing Loss.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundMR Tractography enables non-invasive preoperative depiction of language subcortical tracts, which is crucial for the presurgical work-up of brain tumors; however, it cannot evaluate the exact function of the fibers. PURPOSE: A systematic pipeline was developed to combine tractography reconstruction of language fiber bundles, based on anatomical landmarks (Anatomical-T), with language fMRI cortical activations. A fMRI-targeted Tractography (fMRI-T) was thus obtained, depicting the subsets of the anatomical tracts whose endpoints are located inside a fMRI activation. We hypothesized that fMRI-T could provide additional functional information regarding the subcortical structures, better reflecting the eloquent white matter structures identified intraoperatively.
methodsBoth Anatomical-T and fMRI-T of language fiber tracts were performed on 16 controls and preoperatively on 16 patients with left-hemisphere brain tumors, using a
resultsMNI Atlases showed that fMRI-T is a subset of Anatomical-T, and that different task-specific fMRI-T involve both shared subsets and task-specific subsets - e.g., verbal fluency fMRI-T strongly involves dorsal frontal tracts, consistently with the phonogical-articulatory features of this task. A quantitative analysis in patients revealed that Anatomical-T removed portions of AF-SLF and IFOF were significantly greater than verbal fluency fMRI-T ones, suggesting that fMRI-T is a more specific approach. In addition, qualitative analyses showed that fMRI-T AF-SLF and IFOF predict the exact functional limits of resection with increased specificity when compared to Anatomical-T counterparts, especially the superior frontal portion of IFOF, in a subcohort of patients.
conclusionThese results suggest that performing fMRI-T in addition to the 'classic' Anatomical-T may be useful in a preoperative setting to identify the 'high-risk subsets' that should be spared during the surgical procedure.
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