Evidence map›Paper›PMID 32296278›Full record

ArticlePaediatrics & child health2020

Third-generation cephalosporin-resistant urinary tract infections in children presenting to the paediatric emergency department.

Kristopher T Kang, Karen Ng, Jennifer Kendrick, Peter Tilley, Joseph Ting, Shahrad Rassekh, Srinivas Murthy, Ashley Roberts

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatrics & child health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kristopher T KangDepartment of Pediatrics, University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia.ORCID 0000-0002-5144-3800
Karen NgDepartment of Pharmacy, University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia.
Jennifer KendrickDepartment of Pharmacy, University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia.
Peter TilleyDepartment of Pathology and Laboratory Medicine, University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia.
Joseph TingDepartment of Pediatrics, University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia.
Shahrad RassekhDepartment of Pediatrics, University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia.
Srinivas MurthyDepartment of Pediatrics, University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia.
Ashley RobertsDepartment of Pediatrics, University of British Columbia and British Columbia Children's Hospital, Vancouver, British Columbia.
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of antibiotic-resistant urinary tract infections (UTIs) in children is increasing. The purpose of this study was to describe the incidence, clinical characteristics, and risk factors for third-generation cephalosporin-resistant UTIs presenting to the paediatric emergency department (ED).

methodsThis was a retrospective cohort study conducted at British Columbia Children's Hospital. Children aged 0 to 18 years old presenting to the ED between July 1, 2013 and June 30, 2014 and were found to have UTI due to Enterobacteriaceae and Pseudomonas species were included. Patient demographics, clinical features, laboratory findings, and outcomes were compared using standard statistical analyses. Risk factors for resistant UTIs were analyzed using multiple logistic regression analysis.

resultsThere were 294 eligible patients. The median age was 27.4 months. A third-generation cephalosporin-resistant organism was identified in 36 patients (12%). Patients with resistant UTI had lower rates of appropriate empiric antibiotic therapy (25% versus 95.3%, P<0.05), higher rates of hospitalization (38.9% versus 21.3%, P<0.05), higher rates of undergoing a voiding cystourethrogram (19.4% versus 5.0%, P<0.05), and higher rates of UTI recurrence within 30 days (13.9% versus 4.7%, P<0.05). In multivariate analysis, recent hospitalization (odds ratio [OR] 4.3, confidence interval [CI] 1.2 to 16) and antibiotic therapy (OR 3.5, CI 1.5 to 8.5) within the previous 30 days were risk factors for resistant UTI.

conclusionsThird-generation cephalosporin-resistant organisms account for a significant proportion of community-acquired paediatric UTIs. Recent hospitalization and antibiotic use are associated with increased risk of resistant UTI.

Indexed as

Antibiotic resistanceAntimicrobial stewardshipUrinary tract infections

Identifiers

PMID32296278
PMCPMC7147700
OpenAlexW2911227484

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.