ArticleNature2020
A reference map of the human binary protein interactome.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 699 papers.
0numbers the graph read from it
0cells of the map it votes in
699citing papers in PubMed
65.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
699 citing papers in PubMed, 1,284 citations in OpenAlex.
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639 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
88 authors at 17 institutions in 9 countries.
Katja Luck *Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Dae-Kyum Kim *Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Luke Lambourne *Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7001-7575
Kerstin Spirohn *Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2071-1606
Bridget E BeggCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Wenting BianCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Ruth BrignallCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Tiziana CafarelliCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Francisco J Campos-LaborieCancer Research Center (CiC-IBMCC, CSIC/USAL), Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca (USAL), Salamanca, Spain.
Benoit CharloteauxCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Dongsic ChoiThe Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada.
Atina G CotéCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Meaghan DaleyCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Steven DeimlingDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Alice DesbuleuxCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Amélie DricotCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Marinella GebbiaCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Madeleine F HardyCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Nishka KishoreCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Jennifer J KnappCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
István A KovácsCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Irma LemmensCenter for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.
Miles W MeeThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Joseph C MellorCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Carl PollisCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Carles PonsInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Catalonia, Spain.
Aaron D RichardsonCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Sadie SchlabachCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Bridget TeekingCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Anupama YadavCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5338-0455
Mariana BaborCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Dawit BalchaCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Omer BashaDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Christian Bowman-ColinDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Suet-Feung ChinCancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-5697-1082
Soon Gang ChoiCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0314-3958
Claudia ColabellaDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.ORCID http://orcid.org/0000-0002-2156-4150
Georges CoppinCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Cassandra D'AmataDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
David De RidderCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Steffi De RouckCenter for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.
Miquel Duran-FrigolaInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Catalonia, Spain.
Hanane EnnajdaouiCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Florian GoebelsThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Liana GoehringDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Anjali GopalCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Ghazal HaddadCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Elodie HatchiDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Mohamed HelmyThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-9561-7956
Yves JacobDépartement de Virologie, Unité de Génétique Moléculaire des Virus à ARN (GMVR), Institut Pasteur, UMR3569, Centre National de la Recherche Scientifique (CNRS), Paris, France.ORCID http://orcid.org/0000-0001-9125-2374
Yoseph KassaCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Serena LandiniDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Roujia LiCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Natascha van LieshoutCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Andrew MacWilliamsCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Dylan MarkeyCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Joseph N PaulsonDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8221-7139
Sudharshan RangarajanCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
John RaslaCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Ashyad RayhanCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Thomas RollandCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Adriana San-MiguelCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Yun ShenCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Dayag SheykhkarimliCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8415-6659
Gloria M SheynkmanCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Eyal SimonovskyDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Murat TaşanCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Alexander TejedaCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Vincent TropepeDepartment of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Jean-Claude TwizereMolecular Biology of Diseases, Groupe Interdisciplinaire de Génomique Appliquée (GIGA) and Laboratory of Viral Interactomes, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-8683-705X
Yang WangCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Robert J WeatherittThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Jochen WeileCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Yu XiaCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5596-5518
Xinping YangCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Esti Yeger-LotemDepartment of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.ORCID http://orcid.org/0000-0002-8279-7898
Quan ZhongCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2910-5597
Patrick AloyInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute for Science and Technology, Barcelona, Catalonia, Spain.
Gary D BaderThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-0185-8861
Javier De Las RivasCancer Research Center (CiC-IBMCC, CSIC/USAL), Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca (USAL), Salamanca, Spain.ORCID http://orcid.org/0000-0002-0984-9946
Suzanne GaudetCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.
Tong HaoCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7908-3256
Janusz RakThe Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, Quebec, Canada.ORCID http://orcid.org/0000-0002-2912-5566
Jan TavernierCenter for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.
David E HillCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. david_hill@dfci.harvard.edu.ORCID http://orcid.org/0000-0001-5192-0921
Marc VidalCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. marc_vidal@dfci.harvard.edu.
Frederick P RothCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. fritz.roth@utoronto.ca.ORCID http://orcid.org/0000-0002-6628-649X
Michael A CalderwoodCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA. michael_calderwood@dfci.harvard.edu.ORCID http://orcid.org/0000-0001-6475-1418
Harvard University · USUniversity of Toronto · CAMount Sinai Hospital · CABen-Gurion University of the Negev · ILConsejo Superior de Investigaciones Científicas · ESInstitute for Research in Biomedicine · ESMcGill University Health Centre · CAVlaams Instituut voor Biotechnologie · BECanadian Institute for Advanced Research · CACentre National de la Recherche Scientifique · FRDana-Farber Cancer Institute · USInstitució Catalana de Recerca i Estudis Avançats · ESNortheastern University · USUniversidad de Salamanca · ESUniversity of Cambridge · GBUniversity of Liège · BEUniversity of Perugia · IT
Funding
Genomic Analysis of Network Perturbations in Human DiseaseP50HG004233 · NHGRI · DANA-FARBER CANCER INST · PI VIDAL, MARC · 2007 to 2017
$31.6MCenter for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4MMapping Transcriptional Networks in Cardiac DevelopmentU01HL098166 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2009 to 2014
$9.5MTumor Cell Biology Training ProgramT32CA009361 · NCI · DANA-FARBER CANCER INSTITUTE · PI GRAY, NATHANAEL SCHIANDER · 1985 to 2015
$8.9MResource ProjectU41HG001715 · NHGRI · DANA-FARBER CANCER INST · PI VIDAL, MARC · 2015 to 2017
$4.7MFunctional Profiling of Human Disease TargetsR01GM109199 · NIGMS · DANA-FARBER CANCER INST · PI CALDERWOOD, MICHAEL A · 2014 to 2017
$1.8MNCI NIH HHS T32 CA009361NHGRI NIH HHS P50 HG004233NHGRI NIH HHS U01 HG007690NHGRI NIH HHS U41 HG001715NHLBI NIH HHS U01 HL098166NIGMS NIH HHS R01 GM109199
Abstract
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships
Indexed as
Extracellular SpaceHumansOrgan SpecificityProtein Interaction MappingProteomeProteome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.