ArticleNature communications2020
Transcriptional repression of GIF1 by the KIX-PPD-MYC repressor complex controls seed size in Arabidopsis.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 77 citations in OpenAlex.
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- Tiny seeds, big decisions: Jasmonate-mediated regulation of seed size in Arabidopsis via the SOD7-KLU module.The Plant cell · 2025Article
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- The adaptor protein ECAP, the corepressor LEUNIG, and the transcription factor BEH3 interact and regulate microsporocyte generation in Arabidopsis.The Plant cell · 2024Article
- A nonsynonymous mutation in BhLS, encoding an acyl-CoA N-acyltransferase leads to fruit and seed size variation in wax gourd (Benincasa hispida).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Understanding the Molecular Regulatory Networks of Seed Size in Soybean.International journal of molecular sciences · 2024Review
- qGLF5 from Oryza rufipogon Griff. improves kernel shape, plant architecture, and yield in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Recent advances in the improvement of soybean seed traits by genome editing.Plant biotechnology (Tokyo, Japan) · 2023Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seed size is a key agronomic trait that greatly determines plant yield. Elucidating the molecular mechanism underlying seed size regulation is also an important question in developmental biology. Here, we show that the KIX-PPD-MYC-GIF1 pathway plays a crucial role in seed size control in Arabidopsis thaliana. Disruption of KIX8/9 and PPD1/2 causes large seeds due to increased cell proliferation and cell elongation in the integuments. KIX8/9 and PPD1/2 interact with transcription factors MYC3/4 to form the KIX-PPD-MYC complex in Arabidopsis. The KIX-PPD-MYC complex associates with the typical G-box sequence in the promoter of GRF-INTERACTING FACTOR 1 (GIF1), which promotes seed growth, and represses its expression. Genetic analyses support that KIX8/9, PPD1/2, MYC3/4, and GIF1 function in a common pathway to control seed size. Thus, our results reveal a genetic and molecular mechanism by which the transcription factors MYC3/4 recruit KIX8/9 and PPD1/2 to the promoter of GIF1 and repress its expression, thereby determining seed size in Arabidopsis.
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