Evidence map›Paper›PMID 32295926›Full record

ArticleJournal of virology2020

Bacterial Pigment Prodigiosin Demonstrates a Unique Antiherpesvirus Activity That Is Mediated through Inhibition of Prosurvival Signal Transducers.

Rahul K Suryawanshi, Lulia Koujah, Chandrashekhar D Patil, Joshua M Ames, Alex Agelidis, Tejabhiram Yadavalli, Satish V Patil, Deepak Shukla

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. A gut commensalVirulence · 2026
    Article
  2. MarinePharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Promising Prodiginins Biological Activities.Chemistry & biodiversity · 2025
    Review
  5. Article
  6. Article
  7. Emerging drugs for the treatment of herpetic keratitis.Expert opinion on emerging drugs · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Rahul K SuryawanshiDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Lulia KoujahDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Chandrashekhar D PatilDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Joshua M AmesDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Alex AgelidisDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Tejabhiram YadavalliDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.
Satish V PatilSchool of Life Sciences, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon, Maharashtra, India.
Deepak ShuklaDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA dshukla@uic.edu.
University of Illinois Chicago · USNorth Maharashtra University · IN

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
A new molecular therapy against ocular herpesR01EY024710 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DEEPAK SHUKLA · 2015 to 2026
$5.2M
HPSE in Ocular Herpes InfectionR01EY029426 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DEEPAK SHUKLA · 2018 to 2026
$3.7M
A small molecule inhibitor of HSV genital infectionsR01AI139768 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHUKLA, DEEPAK · 2018 to 2021
$1.6M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY024710NEI NIH HHS R01 EY029426NIAID NIH HHS R01 AI139768
6 · The paper itself

Abstract

Herpes simplex virus (HSV) is among the most prevalent viral infections worldwide and remains incurable. While nucleoside analogs are used to relieve symptoms of infection, they suffer from having serious adverse effects and are unable to abolish the virus from the host. Here, we demonstrate a unique antiviral effect of prodigiosin (PG), a natural secondary metabolite produced by

Indexed as

AnimalsAntiviral AgentsCell LineCorneaHeLa CellsHerpes SimplexHerpesvirus 1, HumanHerpesvirus 2, HumanHumansMiceMice, Inbred C57BLProdigiosinSerratia marcescensSimplexvirusSwineVirus ReplicationAntiviral AgentsProdigiosinantiviralcell signalingherpesvirusprodigiosin

Identifiers

PMID32295926
PMCPMC7307156
OpenAlexW3016655066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.