Evidence map›Paper›PMID 32295925›Full record

ArticleJournal of virology2020

Ca

Marco R Straus, Tiffany Tang, Alex L Lai, Annkatrin Flegel, Miya Bidon, Jack H Freed, Susan Daniel, Gary R Whittaker

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

  1. Pooled it
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  20. Comparison of trace element (selenium, iron), electrolyte (calcium, sodium), and physical activity levels in COVID-19 patients before and after the treatment.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Marco R Straus *Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA.ORCID 0000-0003-1087-2091
Tiffany Tang *Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA.
Alex L LaiACERT, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Annkatrin FlegelDepartment of Microbiology and Immunology, Cornell University, Ithaca, New York, USA.
Miya BidonRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA.
Jack H FreedACERT, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Susan DanielRobert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA sd386@cornell.edu grw7@cornell.edu.
Gary R WhittakerDepartment of Microbiology and Immunology, Cornell University, Ithaca, New York, USA sd386@cornell.edu grw7@cornell.edu.
Cornell University · US

Funding

TR&D 4 for ACERT, 2017-2021 funding periodP41GM103521 · NIGMS · CORNELL UNIVERSITY · PI FREED, JACK H · 2012 to 2021
$11.7M
Electron Spin Relaxation in Model MembranesR01GM123779 · NIGMS · CORNELL UNIVERSITY · PI FREED, JACK H · 2017 to 2020
$2.1M
X/Q Band Pulsed ENDOR SpectrometerS10OD021543 · OD · CORNELL UNIVERSITY · PI FREED, JACK H · 2016 to 2016
$1.4M
NIGMS NIH HHS P41 GM103521NIGMS NIH HHS R01 GM123779NIH HHS S10 OD021543
6 · The paper itself

Abstract

Fusion with, and subsequent entry into, the host cell is one of the critical steps in the life cycle of enveloped viruses. For Middle East respiratory syndrome coronavirus (MERS-CoV), the spike (S) protein is the main determinant of viral entry. Proteolytic cleavage of the S protein exposes its fusion peptide (FP), which initiates the process of membrane fusion. Previous studies on the related severe acute respiratory syndrome coronavirus (SARS-CoV) FP have shown that calcium ions (Ca

Indexed as

Host-Pathogen InteractionsMembrane FusionVirus InternalizationAmino Acid SequenceAmino Acid SubstitutionAnimalsCalciumCell LineChlorocebus aethiopsCoronavirus InfectionsHumansIonsMiddle East Respiratory Syndrome CoronavirusModels, MolecularMutationProtein BindingCalciumIonsSpike Glycoprotein, Coronaviruscoronavirusfusionfusion peptidemembrane fusionMERSspike proteinviral fusion

Identifiers

PMID32295925
PMCPMC7307142
OpenAlexW3015512747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.