Evidence map›Paper›PMID 32295913›Full record

ArticleJournal of virology2020

Cellular Gene Modulation of HIV-Infected CD4 T Cells in Response to Serial Treatment with the Histone Deacetylase Inhibitor Vorinostat.

Jill W Maxwell, Shane D Falcinelli, Alexey Nefedov, Corin Dorfmeier, Guoxin Wu, Morgan Dewey, Andrea L Webber, Nancie M Archin, David M Margolis, Daria J Hazuda and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jill W Maxwell *Merck & Co., Inc., West Point, Pennsylvania, USA jill_w_maxwell@merck.com nancie_archin@med.unc.edu.
Shane D Falcinelli *UNC HIV Cure Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Alexey NefedovMerck & Co., Inc., West Point, Pennsylvania, USA.
Corin DorfmeierMerck & Co., Inc., West Point, Pennsylvania, USA.
Guoxin WuMerck & Co., Inc., West Point, Pennsylvania, USA.
Morgan DeweyUNC HIV Cure Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Andrea L WebberMerck & Co., Inc., West Point, Pennsylvania, USA.
Nancie M ArchinUNC HIV Cure Center, University of North Carolina, Chapel Hill, North Carolina, USA jill_w_maxwell@merck.com nancie_archin@med.unc.edu.
David M MargolisUNC HIV Cure Center, University of North Carolina, Chapel Hill, North Carolina, USA.
Daria J HazudaMerck & Co., Inc., West Point, Pennsylvania, USA.
Richard J O BarnardMerck & Co., Inc., West Point, Pennsylvania, USA.
Bonnie J HowellMerck & Co., Inc., West Point, Pennsylvania, USA.
United States Military Academy · USUniversity of North Carolina at Chapel Hill · US

Funding

Collaboratory of AIDS Researchers for Eradication (CARE)UM1AI126619 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARGOLIS, DAVID M. · 2016 to 2020
$23.2M
The HIV Reservoir in Women: Implications for HIV cure interventionsR01AI134363 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARCHIN, NANCIE MARIE · 2017 to 2020
$2.2M
Reducing the HIV Reservoir: Next-Generation Latency Reversal Agents and T Cell Population TargetsF30AI145588 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FALCINELLI, SHANE DAVID · 2019 to 2023
$217k
NIAID NIH HHS F30 AI145588NIAID NIH HHS R01 AI134363NIAID NIH HHS UM1 AI126619
6 · The paper itself

Abstract

Histone deacetylase inhibitors (HDACi) are the most widely studied HIV latency-reversing agents (LRAs). The HDACi suberoylanilide hydroxamic acid (vorinostat [VOR]) has been employed in several clinical HIV latency reversal studies, as well as

Indexed as

AcetylationCD4-Positive T-LymphocytesHistone Deacetylase InhibitorsHIV-1HIV InfectionsHumansJurkat CellsLeukocytes, MononuclearPrimary Cell CultureVirus ActivationVirus LatencyVorinostatHistone Deacetylase InhibitorsVorinostatbiomarkergene expressionhistone deacetylase inhibitorshuman immunodeficiency virusvorinostat

Identifiers

PMID32295913
PMCPMC7307144
OpenAlexW3016797220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.