Evidence map›Paper›PMID 32295905›Full record

ArticleJournal of virology2020

Insights into the Role of Innate Immunity in Cervicovaginal Papillomavirus Infection from Studies Using Gene-Deficient Mice.

Carolina Scagnolari, Fabiana Cannella, Alessandra Pierangeli, Rebecca Mellinger Pilgrim, Guido Antonelli, Dayana Rowley, Margaret Wong, Simon Best, Deyin Xing, Richard B S Roden and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

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  17. A prognostic value of CD45RAScientific reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Carolina ScagnolariLaboratory of Virology, Department of Molecular Medicine, Sapienza University, Rome, Italy carolina.scagnolari@uniroma1.it rviscid1@jhmi.edu.
Fabiana CannellaLaboratory of Virology, Department of Molecular Medicine, Sapienza University, Rome, Italy.
Alessandra PierangeliLaboratory of Virology, Department of Molecular Medicine, Sapienza University, Rome, Italy.
Rebecca Mellinger PilgrimDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Guido AntonelliLaboratory of Virology, Department of Molecular Medicine, Sapienza University, Rome, Italy.
Dayana RowleyDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Margaret WongDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Simon BestDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Deyin XingDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Richard B S RodenDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-2506-0195
Raphael ViscidiDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA carolina.scagnolari@uniroma1.it rviscid1@jhmi.edu.
Johns Hopkins University · USIstituto Pasteur · IT

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI TZYY-CHOOU WU · 2003 to 2026
$53.5M
Mouse modeling of HPV infectionR01CA233486 · NCI · JOHNS HOPKINS UNIVERSITY · PI HUNG, CHIEN-FU, RODEN, RICHARD BRUCE · 2019 to 2023
$3.0M
Development of Novel Spontaneous HPV Cervicovaginal Carcinoma Models for Cancer ImmunotherapyR01CA237067 · NCI · JOHNS HOPKINS UNIVERSITY · PI WU, TZYY-CHOOU · 2019 to 2023
$2.9M
NCI NIH HHS P30 CA006973NCI NIH HHS P50 CA098252NCI NIH HHS R01 CA233486NCI NIH HHS R01 CA237067
6 · The paper itself

Abstract

We demonstrate that female C57BL/6J mice are susceptible to a transient lower genital tract infection with MmuPV1 mouse papillomavirus and display focal histopathological abnormalities resembling those of human papillomavirus (HPV) infection. We took advantage of strains of genetically deficient mice to study

Indexed as

Adaptor Proteins, Signal TransducingAlternative SplicingAnimalsCaspase 1Cervix UteriFemaleGene Expression RegulationHost-Pathogen InteractionsHumansImmunity, InnateMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMyeloid Differentiation Factor 88PapillomaviridaeAdaptor Proteins, Signal TransducingCasp1 protein, mouseCaspase 1CCR6 protein, mouseCxcr2 protein, mouseCxcr3 protein, mouseIL1R1 protein, mouseMAVS protein, mouseMembrane ProteinsMyd88 protein, mouseMyeloid Differentiation Factor 88Receptor-Interacting Protein Serine-Threonine Kinase 2Receptors, CCR6Receptors, CXCR3Receptors, Interleukin-1 Type IReceptors, Interleukin-8BRipk2 protein, mouseRNA, MessengerRNA, ViralStat1 protein, mouseSTAT1 Transcription FactorSting1 protein, mouseSTING Proteininnate immunitypapillomaviruses

Identifiers

PMID32295905
PMCPMC7307098
OpenAlexW3015358978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.