Evidence map›Paper›PMID 32295878›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses.

Saikiran K Sedimbi, Thomas Hägglöf, Manasa G Garimella, Shan Wang, Amanda Duhlin, Ana Coelho, Katrine Ingelshed, Emma Mondoc, Stephen G Malin, Rikard Holmdahl and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Innate immunity and early liver inflammation.Frontiers in immunology · 2023
    Review
  4. Review
  5. Article
  6. NKT Cells Contribute to the Control of Microbial Infections.Frontiers in cellular and infection microbiology · 2021
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Saikiran K SedimbiDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden; saikiran.sedimbi@ki.se mikael.karlsson@ki.se.
Thomas HägglöfDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Manasa G GarimellaDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Shan WangDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Amanda DuhlinDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Ana CoelhoDivision of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
Katrine IngelshedDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Emma MondocHistology Core Facility, Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0001-9678-4126
Stephen G MalinDepartment of Medicine, Karolinska Institutet and Karolinska University Hospital, 17176 Stockholm, Sweden.ORCID 0000-0001-7723-9579
Rikard HolmdahlDivision of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0002-4969-2576
David P LaneDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Elizabeth A LeadbetterDepartment of Microbiology and Immunology, University of Texas School of Medicine Health Science Center at San Antonio, San Antonio, Texas, 78229.
Mikael C I KarlssonDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden; saikiran.sedimbi@ki.se mikael.karlsson@ki.se.
Karolinska Institutet · SEThe University of Texas Health Science Center at San Antonio · USKarolinska University Hospital · SE

Funding

iNKT and B Cell Cooperation in Immunity and Host DefenseR56AI104788 · NIAID · TRUDEAU INSTITUTE, INC. · PI LEADBETTER, ELIZABETH ANN · 2014 to 2014
$244k
NIAID NIH HHS R56 AI104788
6 · The paper itself

Abstract

Invariant natural killer T (

Indexed as

AutoimmunityAnimalsAntibodies, AntinuclearB-LymphocytesChronic DiseaseDisease Models, AnimalFemaleGalactosylceramidesHumansInflammationInjections, IntraperitonealInterleukin-18MaleMiceMice, TransgenicNatural Killer T-Cellsalpha-galactosylceramideAntibodies, AntinuclearGalactosylceramidesInterleukin-18Recombinant ProteinsautoimmunityB cellsinflammationneutrophilsNKT cells

Identifiers

PMID32295878
PMCPMC7183147
OpenAlexW3016299692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.