Evidence map›Paper›PMID 32295832›Full record

ArticleBiology open2020

Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia.

Thomas Weber, Lars Schlotawa, Roland Dosch, Noémie Hamilton, Jens Kaiser, Stina Schiller, Britta Wenske, Jutta Gärtner, Marco Henneke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Thomas WeberDepartment of Pediatrics and Adolescent Medicine, University Medical Center Goettingen, Robert- Koch- Str. 40, 37075 Goettingen, Germany hennekem@med.uni-goettingen.de thomasweber488@gmail.com.ORCID 0000-0002-3430-9589
Lars SchlotawaDepartment of Pediatrics and Adolescent Medicine, University Medical Center Goettingen, Robert- Koch- Str. 40, 37075 Goettingen, Germany.
Roland DoschDepartment of Human Genetics, University Medical Center Goettingen, Justus-von-Liebig-Weg 11, 37077 Goettingen, Germany.
Noémie HamiltonThe Bateson Centre, University of Sheffield, Firth Court D31, Sheffield S10 2PT, United Kingdom.ORCID 0000-0002-3299-9133
Jens KaiserDepartment of Pediatrics and Adolescent Medicine, University Medical Center Goettingen, Robert- Koch- Str. 40, 37075 Goettingen, Germany.
Stina SchillerDepartment of Pediatrics and Adolescent Medicine, University Medical Center Goettingen, Robert- Koch- Str. 40, 37075 Goettingen, Germany.
Britta WenskeDepartment of Haematology and Oncology, University Medical Center Goettingen, Robert- Koch- Str. 40, 37075 Goettingen, Germany.
Jutta GärtnerDepartment of Pediatrics and Adolescent Medicine, University Medical Center Goettingen, Robert- Koch- Str. 40, 37075 Goettingen, Germany.
Marco HennekeDepartment of Pediatrics and Adolescent Medicine, University Medical Center Goettingen, Robert- Koch- Str. 40, 37075 Goettingen, Germany hennekem@med.uni-goettingen.de thomasweber488@gmail.com.ORCID 0000-0003-2188-5066
University of Göttingen · DEJustus-Liebig-Universität Gießen · DEUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human infantile-onset RNASET2-deficient cystic leukoencephalopathy is a Mendelian mimic of

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseasePhenotypeAnimalsApoptosisDisease SusceptibilityHumansLarvaLeukoencephalopathiesMicrogliaNeuronsOrganogenesisRhombencephalonRibonucleasesTumor Suppressor ProteinsZebrafishRibonucleasesRNASET2 protein, humanTumor Suppressor ProteinsCystic leukoencephalopathyInnate immune systemLysosomesRNASET2Zebrafish

Identifiers

PMID32295832
PMCPMC7225086
OpenAlexW3016720353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.