Evidence map›Paper›PMID 32295830›Full record

ArticleBiology open2020

A long lost key opens an ancient lock:

Paul J Vorster, Paul Goetsch, Tilini U Wijeratne, Keelan Z Guiley, Laura Andrejka, Sarvind Tripathi, Braden J Larson, Seth M Rubin, Susan Strome, Joseph S Lipsick

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Paul J VorsterDepartments of Pathology, Genetics, and Biology, Stanford University, Stanford, CA 94305-5324, USA.ORCID 0000-0002-2478-7720
Paul GoetschDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0002-7120-0945
Tilini U WijeratneDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Keelan Z GuileyDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0002-8149-4262
Laura AndrejkaDepartments of Pathology, Genetics, and Biology, Stanford University, Stanford, CA 94305-5324, USA.ORCID 0000-0002-2202-5626
Sarvind TripathiDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0002-6959-0577
Braden J LarsonDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Seth M RubinDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0002-1670-4147
Susan StromeDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0001-9496-7412
Joseph S LipsickDepartments of Pathology, Genetics, and Biology, Stanford University, Stanford, CA 94305-5324, USA lipsick@stanford.edu.ORCID 0000-0001-9231-571X
University of California, Santa Cruz · USStanford University · US

Funding

IMMUNOLOGIC STUDY OF GERM GRANULES IN C. ELEGANS EMBRY0SR01GM034059 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1985 to 2020
$8.9M
Training Program/Molecular/Cell/Developmental BiologyT32GM008646 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STROME, SUSAN · 1999 to 2018
$3.7M
Molecular Mechanisms Regulating the Retinoblastoma Protein FamilyR01CA132685 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI RUBIN, SETH MICHAEL · 2008 to 2017
$3.0M
Biology of the Myb-MuvB Oncoprotein-Tumor Suppressor Protein ComplexR01CA128836 · NCI · STANFORD UNIVERSITY · PI LIPSICK, JOSEPH STEVEN · 2007 to 2016
$2.6M
Structural Mechanisms Controlling Cell-Cycle Gene ExpressionR01GM124148 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI RUBIN, SETH MICHAEL · 2018 to 2021
$1.5M
Cell cycle control through DREAM and MMB complexesF31CA206244 · NCI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI GUILEY, KEELAN ZACHARY · 2016 to 2017
$77k
NCI NIH HHS F31 CA206244NCI NIH HHS R01 CA128836NCI NIH HHS R01 CA132685NIGMS NIH HHS R01 GM034059NIGMS NIH HHS R01 GM124148NIGMS NIH HHS T32 GM008646
6 · The paper itself

Abstract

The five-protein MuvB core complex is highly conserved in animals. This nuclear complex interacts with RB-family tumor suppressor proteins and E2F-DP transcription factors to form DREAM complexes that repress genes that regulate cell cycle progression and cell fate. The MuvB core complex also interacts with Myb family oncoproteins to form the Myb-MuvB complexes that activate many of the same genes. We show that animal-type

Indexed as

Gene Expression RegulationGenetic Association StudiesPhenotypeAmino Acid SequenceAnimalsBiological EvolutionCell Cycle ProteinsDrosophilaDrosophila ProteinsEvolution, MolecularHumansModels, MolecularPhylogenyProtein ConformationProtein SubunitsProto-Oncogene Proteins c-mybCell Cycle ProteinsDrosophila ProteinsMyb protein, DrosophilaProtein SubunitsProto-Oncogene Proteins c-mybDevelopmentEvolutionMybOncogenesynMuvTumor suppressor

Identifiers

PMID32295830
PMCPMC7225089
OpenAlexW3016292140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.