ArticleNeurology2020
White matter hyperintensities mediate the association of nocturnal blood pressure with cognition.
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Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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21citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The Clinical Significance of Ambulatory Blood Pressure on Cerebral Small Vessel disease. A Systematic Review and meta-analysis of the Literature.Current hypertension reports · 2025Pooled it
- Association between ambulatory blood pressure monitoring patterns with cognitive function and risk of dementia: a systematic review and meta-analysis.Aging clinical and experimental research · 2023Pooled it
- Nighttime Systolic Blood Pressure, Neuroaxonal Injury, and Cognitive Impairment in Intracranial Atherosclerotic Stenosis.Journal of the American Heart Association · 2026Observational
- Elevated Cumulative Blood Pressure is Associated With Cognitive Decline: A Nationwide Population-Based Cohort Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- A reset on our reclined position-a call to prioritize neurogenic supine hypertension in the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- Association Between the Circadian Rhythm of Arterial Blood Pressure and White Matter Lesions in Hospitalized Hypertensive Patients: A Cross-Sectional Study.International journal of general medicine · 2025Article
- Effect of the duration of hypertension on white matter structure and its link with cognition.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Twenty-four hour blood pressure variability and the prevalence and the progression of cerebral white matter hyperintensities.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Heart rate variability in congenital central hypoventilation syndrome: relationships with hypertension and sinus pauses.Pediatric research · 2023Article
- Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report.Hypertension (Dallas, Tex. : 1979) · 2023Review
- White matter changes underlie hypertension-related cognitive decline in older adults.NeuroImage. Clinical · 2023Review
- Association of brain morphology and phenotypic profile in patients with unruptured intracranial aneurysm.Frontiers in aging neuroscience · 2023Article
- Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study).Journal of the American Heart Association · 2022Article
- Subclinical Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Relation to Office and Ambulatory Blood Pressure Measurements.Frontiers in neurology · 2022Article
- Sleep and circadian rhythms: pillars of health-a Keystone Symposia report.Annals of the New York Academy of Sciences · 2021Review
- Blood Pressure Profiles and Cognitive Function from Adulthood to Old Age: Chasing a Golden Middle Way?Journal of clinical medicine · 2021Review
- Author Response: White Matter Hyperintensities Mediate the Association of Nocturnal Blood Pressure With Cognition.Neurology · 2021Article
- Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment.Translational stroke research · 2021Article
- Total Plasma Homocysteine and Depressive Symptoms in Older Hispanics.Journal of Alzheimer's disease : JAD · 2021Article
- White Matter Hyperintensities in the Synucleinopathies: Orthostatic Hypotension, Supine Hypertension, or Both?Movement disorders clinical practice · 2020Article
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Authors and funding
13 authors at 1 institution in 2 countries.
Anthony G ChesebroFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Jesus D MelgarejoFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Reinier LeendertzFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Kay C IgweFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Patrick J LaoFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Krystal K LaingFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Batool RizviFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Mariana BudgeFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Irene B MeierFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Gustavo CalmonFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Joseph H LeeFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Gladys E MaestreFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville.
Adam M BrickmanFrom the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (A.G.C., K.C.I., P.J.L., K.K.L., B.R., M.B., I.B.M., J.H.L., A.M.B.), Gertrude H. Sergievsky Center (J.H.L., A.M.B.), and Department of Neurology (J.H.L., A.M.B.), College of Physicians and Surgeons, and Department of Epidemiology (J.H.L.), Joseph P. Mailman School of Public Health, Columbia University, New York, NY; Laboratory of Neurosciences (J.D.M., R.L., G.E.M.) and Laboratory of Cardiovascular Registry (G.C.), Cardiovascular Institute, University of Zulia, Maracaibo, Venezuela; and Departments of Neuroscience and Human Genetics (G.M.), School of Medicine, University of Texas Rio Grande Valley, Brownsville. amb2139@columbia.edu.ORCID 0000-0002-5125-8226
MACOM (United States) · US
Funding
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes · 2021 to 2026
$24.0MGene-Environment Interactions in Cognition in Venezuelan FamiliesR01AG036469 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHACON, INARA, MAESTRE, GLADYS E. · 2011 to 2015
$2.7MNIA NIH HHS P30 AG066546NIA NIH HHS R01 AG036469
Abstract
objectiveTo test the hypotheses that hypertension and nocturnal blood pressure are related to white matter hyperintensity (WMH) volume, an MRI marker of small vessel cerebrovascular disease, and that WMH burden statistically mediates the association of hypertension and dipping status with memory functioning, we examined the relationship of hypertension and dipping status on WMH volume and neuropsychological test scores in middle-aged and older adults.
methodsParticipants from the community-based Maracaibo Aging Study received ambulatory 24-hour blood pressure monitoring, structural MRI, and neuropsychological assessment. Four hundred thirty-five participants (mean ± SD age 59 ± 13 years, 71% women) with available ambulatory blood pressure, MRI, and neuropsychological data were included in the analyses. Ambulatory blood pressure was used to define hypertension and dipping status (i.e., dipper, nondipper, and reverse dipper based on night/day blood pressure ratio <0.9, 0.9-1, and >1, respectively). Outcome measures included regional WMH and memory functioning derived from a neuropsychological test battery.
resultsThe majority of the participants (59%) were hypertensive. Ten percent were reverse dippers, and 40% were nondippers. Reverse dipping in the presence of hypertension was associated with particularly elevated periventricular WMH volume (
conclusionReverse dipping in the presence of hypertension is associated with small vessel cerebrovascular disease, which, in turn, mediates memory functioning. These results point toward reverse dipping as a marker of poor nocturnal blood pressure control, particularly among hypertensive individuals, with potentially pernicious effects on cerebrovascular health and associated cognitive function.
Indexed as
CognitionAgedBlood PressureBlood Pressure Monitoring, AmbulatoryCerebrovascular DisordersFemaleHumansHypertensionLeukoencephalopathiesMagnetic Resonance ImagingMaleMiddle AgedWhite Matter
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