Evidence map›Paper›PMID 32295644›Full record

ReviewWorld journal of emergency surgery : WJES2020

Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines.

Salomone Di Saverio, Mauro Podda, Belinda De Simone, Marco Ceresoli, Goran Augustin, Alice Gori, Marja Boermeester, Massimo Sartelli, Federico Coccolini, Antonio Tarasconi and 50 more

7 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of emergency surgery : WJES, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 600 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
600citing papers in PubMed, 8 pooled it
161.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04730752 completednot on this mapstarted 2021, after this paper: background citation

Prospective Clinical Trial on Validation and Comparison of the Diagnostic and Prognostic Value of Appendicitis Inflammatory Response Score and Adult Appendicitis Score

TypeobservationalSponsorNigde Omer Halisdemir UniversityRan2021 to 2021Enrolled174ConditionsAcute Appendicitis, Acute Appendicitis With RuptureArmsAppendicitis Inflammatory Response, Adult Appendicitis Score
NCT05202483 completednot on this mapstarted 2021, after this paper: background citation

A Novel Appendicitis TriMOdal Prediction Score (ATMOS) for Acute Appendicitis in Pregnancy: a Retrospective Observational Study

TypeobservationalSponsorClinical Hospital Centre ZagrebRan2021 to 2021Enrolled60ConditionsAppendicitis in Pregnancy
NCT05401188 nacompletednot on this map

Randomized Clinical Trial to Test the Efficacy and Safety of Outpatient Clinical Management of Urgent Laparoscopic Appendectomy in Uncomplicated Acute Appendicitis

TypeinterventionalSponsorHJ23Ran2019 to 2022Enrolled120ConditionsAppendicitis Acute, AppendicitisArmsOutpatient, hospitalization
NCT05407922 unknown statusnot on this mapstarted 2022, after this paper: background citation

Laparoscopic Value in the Management of Acute Abdomen During Pregnancy

TypeobservationalSponsorSohag UniversityRan2022 to 2023Enrolled50ConditionsAcute Abdomen, Pregnancy RelatedArmsLaparoscopy vs Non-laparoscopy approach
NCT06059365 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Randomized Clinical Trial to Test the Efficacy and Safety of Outpatient Clinical Management of Urgent Laparoscopic Appendectomy in Complicated Acute Appendicitis

TypeinterventionalSponsorHJ23Ran2023 to 2023Enrolled92ConditionsAcute Appendicitis, Appendicitis Perforated, Appendicitis SuppurativeArmsHospitalization, Outpatient
NCT07401407 completednot on this mapstarted 2022, after this paper: background citation

APENERAS: A Prospective Multicenter Observational Study of RICA (ERAS) Pathway Adherence, Safety Outcomes, and Early Discharge Feasibility in Adults Undergoing Urgent Uncomplicated Appendectomy

TypeobservationalSponsorHospital Galdakao-UsansoloRan2022 to 2025Enrolled193ConditionsAcute Appendicitis, Appendectomy, Ambulatory Surgery
NCT07496723 recruitingnot on this mapstarted 2026, after this paper: background citation

Prospective Evaluation of the Impact of Computed Tomography Reporting and AIR Scoring System on Negative Appendectomy Rates in Patients With Acute Appendicitis

TypeobservationalSponsorSanliurfa Education and Research HospitalRan2026 to 2027Enrolled200ConditionsAcute Appendicitis
3 · Its place in the literature

Who cites it

600 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,291 citations in OpenAlex.

  1. Pooled it
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  3. Effectiveness and Safety of Shortened Postoperative Antibiotic Regimens in Children with Perforated Appendicitis: A Systematic Review and Meta-Analysis.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2026
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540 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

60 authors at 20 institutions in 20 countries.

Salomone Di SaverioCambridge Colorectal Unit, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK. salo75@inwind.it.
Mauro PoddaDepartment of General and Emergency Surgery, Cagliari University Hospital, Cagliari, Italy.
Belinda De SimoneEmergency and Trauma Surgery Department, Maggiore Hospital of Parma, Parma, Italy.
Marco CeresoliEmergency and General Surgery Department, University of Milan-Bicocca, Milan, Italy.
Goran AugustinDepartment of Surgery, University Hospital Centre of Zagreb, Zagreb, Croatia.
Alice GoriMaggiore Hospital Regional Emergency Surgery and Trauma Center, Bologna Local Health District, Bologna, Italy.
Marja BoermeesterDepartment of Surgery, University of Amsterdam, Amsterdam, The Netherlands.
Massimo SartelliMacerata Hospital, Macerata, Italy.
Federico CoccoliniGeneral, Emergency and Trauma Surgery, Pisa University Hospital, Pisa, Italy.
Antonio TarasconiEmergency and Trauma Surgery Department, Maggiore Hospital of Parma, Parma, Italy.
Nicola De' AngelisDepartment of Digestive, Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Henri Mondor University Hospital, Paris, France.
Dieter G WeberTrauma and General Surgeon Royal Perth Hospital & The University of Western Australia, Perth, Australia.
Matti TolonenDepartment of Abdominal Surgery, Abdominal Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Arianna BirindelliDepartment of General Surgery, Azienda Socio Sanitaria Territoriale, di Valle Camonica, Italy.
Walter BifflQueen's Medical Center, University of Hawaii, Honolulu, HI, USA.
Ernest E MooreDenver Health System - Denver Health Medical Center, Denver, USA.
Michael KellyAcute Surgical Unit, Canberra Hospital, ACT, Canberra, Australia.
Kjetil SoreideDepartment of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway.
Jeffry KashukDepartment of Surgery, University of Jerusalem, Jerusalem, Israel.
Richard Ten BroekDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Carlos Augusto GomesDepartment of Surgery Hospital Universitario, Universidade General de Juiz de Fora, Juiz de Fora, Brazil.
Michael SugrueLetterkenny Hospital, Donegal, Ireland.
Richard Justin DaviesCambridge Colorectal Unit, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK.
Dimitrios DamaskosDepartment of Upper GI Surgery, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
Ari LeppäniemiDepartment of Abdominal Surgery, Abdominal Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Andrew KirkpatrickGeneral, Acute Care, Abdominal Wall Reconstruction, and Trauma Surgery, Foothills Medical Centre, Calgary, Alberta, Canada.
Andrew B PeitzmanDepartment of Surgery, University of Pittsburgh School of Medicine, UPMC-Presbyterian, Pittsburgh, USA.
Gustavo P FragaFaculdade de Ciências Médicas (FCM) - Unicamp, Campinas, SP, Brazil.
Ronald V MaierDepartment of Surgery, University of Washington, Harborview Medical Center, Seattle, WA, USA.
Raul CoimbraUCSD Health System - Hillcrest Campus Department of Surgery Chief Division of Trauma, Surgical Critical Care, Burns, and Acute Care Surgery, San Diego, CA, USA.
Massimo ChiarugiGeneral, Emergency and Trauma Surgery, Pisa University Hospital, Pisa, Italy.
Gabriele SgangaDepartment of Emergency Surgery, "A. Gemelli Hospital", Catholic University of Rome, Rome, Italy.
Adolfo PisanuDepartment of General and Emergency Surgery, Cagliari University Hospital, Cagliari, Italy.
Gian Luigi De' AngelisGastroenterology and Endoscopy Unit, University Hospital of Parma, University of Parma, Parma, Italy.
Edward TanDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Harry Van GoorDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Francesco PataDepartment of Surgery, Nicola Giannettasio Hospital, Corigliano-Rossano, and La Sapienza University of Rome, Rome, Italy.
Isidoro Di CarloDepartment of Surgical Sciences and Advanced Technologies "GF Ingrassia", Cannizzaro Hospital, University of Catania, Catania, Italy.
Osvaldo ChiaraNiguarda Hospital Trauma Center, Milan, Italy.
Andrey LitvinDepartment of Surgery, Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Fabio C CampanileDepartment of Surgery, San Giovanni Decollato Andosilla Hospital, Viterbo, Italy.
Boris SakakushevGeneral Surgery Department, Medical University, University Hospital St George, Plovdiv, Bulgaria.
Gia TomadzeDepartment of Surgery, Tbilisi State Medical University, TSMU, Tbilisi, Georgia.
Zaza DemetrashviliDepartment of Surgery, Tbilisi State Medical University, TSMU, Tbilisi, Georgia.
Rifat LatifiSection of Acute Care Surgery, Westchester Medical Center, Department of Surgery, New York Medical College, Valhalla, NY, USA.
Fakri Abu-ZidanDepartment of Surgery, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates.
Oreste RomeoBronson Trauma Surgery, Kalamazoo, USA.
Helmut Segovia-LohseHospital de Clinicas, Universidad Nacional de Asuncion, Asuncion, Paraguay.
Gianluca BaiocchiSurgical Clinic, Department of Experimental and Clinical Sciences, University of Brescia, Brescia, Italy.
David CostaHospital universitario de Alicante, departamento de Cirugia General, Alicante, Spain.
Sandro RizoliDepartment of Surgery, St. Michael Hospital, University of Toronto, Toronto, Canada.
Zsolt J BaloghDepartment of Traumatology, John Hunter Hospital and University of Newcastle, Newcastle, NSW, Australia.
Cino BendinelliDepartment of Traumatology, John Hunter Hospital and University of Newcastle, Newcastle, NSW, Australia.
Thomas ScaleaR. Adams Cowley Trauma Center, Baltimore, MD, USA.
Rao IvaturyProfessor Emeritus Virginia Commonwealth University, Richmond, VA, USA.
George VelmahosHarvard Medical School, Massachusetts General Hospital, Boston, USA.
Roland AnderssonDepartment of Surgery, Linkoping University, Linkoping, Sweden.
Yoram KlugerDivision of General Surgery, Rambam Health Care Campus, Haifa, Israel.
Luca AnsaloniDepartment of General Surgery and Trauma, Bufalini Hospital, Cesena, Italy.
Fausto CatenaEmergency and Trauma Surgery Department, Maggiore Hospital of Parma, Parma, Italy.
Ospedale di Parma · ITRadboud University Nijmegen · NLAzienda Ospedaliera Universitaria Pisana · ITJohn Hunter Hospital · AUTbilisi State Medical University · GEUniversity of Cagliari · ITUniversity of Helsinki · FIAgostino Gemelli University Polyclinic · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITAzienda Socio Sanitaria Territoriale Lariana · ITBronson Methodist Hospital · USCambridge University Hospitals NHS Foundation Trust · GBCanberra Hospital · AUDenver Health Medical Center · USEdinburgh Royal Infirmary · GBFoothills Medical Centre · CAHarvard University · USHebrew University of Jerusalem · ILHôpitaux Universitaires Henri-Mondor · FRHospital General Universitario de Alicante Doctor Balmis · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsAcute appendicitis (AA) is among the most common causes of acute abdominal pain. Diagnosis of AA is still challenging and some controversies on its management are still present among different settings and practice patterns worldwide. In July 2015, the World Society of Emergency Surgery (WSES) organized in Jerusalem the first consensus conference on the diagnosis and treatment of AA in adult patients with the intention of producing evidence-based guidelines. An updated consensus conference took place in Nijemegen in June 2019 and the guidelines have now been updated in order to provide evidence-based statements and recommendations in keeping with varying clinical practice: use of clinical scores and imaging in diagnosing AA, indications and timing for surgery, use of non-operative management and antibiotics, laparoscopy and surgical techniques, intra-operative scoring, and peri-operative antibiotic therapy.

methodsThis executive manuscript summarizes the WSES guidelines for the diagnosis and treatment of AA. Literature search has been updated up to 2019 and statements and recommendations have been developed according to the GRADE methodology. The statements were voted, eventually modified, and finally approved by the participants to the consensus conference and by the board of co-authors, using a Delphi methodology for voting whenever there was controversy on a statement or a recommendation. Several tables highlighting the research topics and questions, search syntaxes, and the statements and the WSES evidence-based recommendations are provided. Finally, two different practical clinical algorithms are provided in the form of a flow chart for both adults and pediatric (< 16 years old) patients.

conclusionsThe 2020 WSES guidelines on AA aim to provide updated evidence-based statements and recommendations on each of the following topics: (1) diagnosis, (2) non-operative management for uncomplicated AA, (3) timing of appendectomy and in-hospital delay, (4) surgical treatment, (5) intra-operative grading of AA, (6) ,management of perforated AA with phlegmon or abscess, and (7) peri-operative antibiotic therapy.

Indexed as

Practice Guidelines as TopicAbdominal PainAcute DiseaseAnti-Bacterial AgentsAppendectomyAppendicitisEvidence-Based MedicineHumansLaparoscopyAnti-Bacterial AgentsAcute appendicitisAdult Appendicitis ScoreAlvarado scoreAntibioticsAppendectomyAppendiceal abscessAppendicitis diagnosis scoreAppendicitis guidelinesComplicated appendicitisConsensus conferenceCT scan appendicitisDiagnostic laparoscopyImagingJerusalem guidelinesLaparoscopic appendectomyNon-operative managementPhlegmon

Identifiers

PMID32295644
PMCPMC7386163
OpenAlexW3017264036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.