ArticleMalaria journal2020
The malaria parasite Plasmodium falciparum in red blood cells selectively takes up serum proteins that affect host pathogenicity.
Article in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Identification of Co-Existing Mutations and Gene Expression Trends Associated With K13-Mediated Artemisinin Resistance inFrontiers in genetics · 2022Pooled it
- Divaricamine B, a new trimeric monoterpenoid Indole alkaloid from Tabernaemontana divaricata.Journal of natural medicines · 2026Article
- Cyclosebistine A, a unique anti-malarial bisindole alkaloid from Catharanthus roseus.Journal of natural medicines · 2026Article
- Physical Signs and Hematological and Biochemical Alterations in Salmonella-Plasmodium Sequentially Coinfected Albino Wistar Rats.TheScientificWorldJournal · 2026Article
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- The fight against malaria in Edo-North, Edo State, Nigeria: identifying risk factors for effective control.PeerJ · 2024Article
- Cultivation of Asexual Intraerythrocytic Stages ofPathogens (Basel, Switzerland) · 2023Review
- Analysis of genome instability and implications for the consequent phenotype inMicrobial genomics · 2023Article
- Article
- Plug for the parasitophorous duct: a solution of two conundra.Malaria journal · 2020Article
- Human plasma plasminogen internalization route in Plasmodium falciparum-infected erythrocytes.Malaria journal · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe malaria parasite Plasmodium falciparum is a protozoan that develops in red blood cells (RBCs) and requires various host factors. For its development in RBCs, nutrients not only from the RBC cytosol but also from the extracellular milieu must be acquired. Although the utilization of host nutrients by P. falciparum has been extensively analysed, only a few studies have reported its utilization of host serum proteins. Hence, the aim of the current study was to comprehensively identify host serum proteins taken up by P. falciparum parasites and to elucidate their role in pathogenesis.
methodsPlasmodium falciparum was cultured with human serum in vitro. Uptake of serum proteins by parasites was comprehensively determined via shotgun liquid chromatography-mass spectrometry/mass spectrometry and western blotting. The calcium ion concentration in serum was also evaluated, and coagulation activity of the parasite lysate was assessed.
resultsThree proteins, vitamin K-dependent protein S, prothrombin, and vitronectin, were selectively internalized under sufficient Ca
conclusionsSerum proteins were taken up by parasites under culture conditions with sufficient Ca
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