Evidence map›Paper›PMID 32295562›Full record

ArticleBMC public health2020

HPV-based cervical cancer screening in Nicaragua: from testing to treatment.

Francesca Holme, Francisco Maldonado, Orlando B Martinez-Granera, Jose Maria Rodriguez, Juan Almendarez, Rose Slavkovsky, Pooja Bansil, Kerry A Thomson, Jose Jeronimo, Silvia de Sanjose

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06921798 (Remote Resilience), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06921798 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Remote Resilience: Novel Applications of mHealth in Nicaragua's Cancer Control Program

TypeinterventionalSponsorUniversity of VirginiaRan2025 to 2029Enrolled3,000ConditionsHPV Infection, Cervical CancersArmsmHealth
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Francesca HolmePATH, Department of Sexual & Reproductive Health, 2201 Westlake Ave., Suite 200, Seattle, WA, 98101, USA. fholme@path.org.
Francisco MaldonadoMovicancer, Rpto. Las Palmas, del Semáforo "El Guanacaste" (Walmart), 200 mts. al Lago, 175 mts. al Este., Casa, #1108, Managua, Nicaragua.
Orlando B Martinez-GraneraMovicancer, Rpto. Las Palmas, del Semáforo "El Guanacaste" (Walmart), 200 mts. al Lago, 175 mts. al Este., Casa, #1108, Managua, Nicaragua.
Jose Maria RodriguezMovicancer, Rpto. Las Palmas, del Semáforo "El Guanacaste" (Walmart), 200 mts. al Lago, 175 mts. al Este., Casa, #1108, Managua, Nicaragua.
Juan AlmendarezMovicancer, Rpto. Las Palmas, del Semáforo "El Guanacaste" (Walmart), 200 mts. al Lago, 175 mts. al Este., Casa, #1108, Managua, Nicaragua.
Rose SlavkovskyPATH, Department of Sexual & Reproductive Health, 2201 Westlake Ave., Suite 200, Seattle, WA, 98101, USA.
Pooja BansilPATH, Department of Sexual & Reproductive Health, 2201 Westlake Ave., Suite 200, Seattle, WA, 98101, USA.
Kerry A ThomsonPATH, Department of Sexual & Reproductive Health, 2201 Westlake Ave., Suite 200, Seattle, WA, 98101, USA.
Jose JeronimoJose Jeronimo Consulting, Damascus, MD, 20872, USA.
Silvia de SanjosePATH, Department of Sexual & Reproductive Health, 2201 Westlake Ave., Suite 200, Seattle, WA, 98101, USA.
Program for Appropriate Technology in Health · USMasimo (United States) · US

Funding

Bill and Melinda Gates Foundation OPP1086544
6 · The paper itself

Abstract

backgroundIn Nicaragua, cervical cancer is the leading cause of cancer death among women. Human papillomavirus (HPV) testing, primarily using self-sampling, was introduced between 2014 and 2018 in three provinces. We analyzed data from the HPV screening program with the goal of describing key characteristics including reach, HPV prevalence, triage and treatment, and factors associated with follow-up completion.

methodsWe analyzed individual-level data from routinely collected forms for women attending HPV-based cervical cancer screening. HPV-positive women were triaged with Pap or visual inspection with acetic acid (VIA) prior to treatment. Logistic regression was used to identify factors associated with receiving triage and treatment; analyses were adjusted for province, age, and self- vs. provider-collected sampling.

resultsForty-four thousand six hundred thirty-five women were screened with HPV testing; 96.6% of women used self-sampling. Six thousand seven hundred seventy-six women were HPV positive (15.2%), 54.0% of screen-positive women received triage, and 53.1% of triage-positive women were treated, primarily with cryotherapy. If women lost at triage are included, the overall treatment percentage was 27.8%. Province and provider sampling were significantly associated with completing triage. Province and triage type were significantly associated with receiving treatment. The odds of receiving treatment after Pap triage as compared to VIA was significantly lower (aOR: 0.05, 95% CI: 0.04-0.08, p < 0.001), and the relative proportion of women receiving treatment after Pap triage versus VIA was 0.29.

conclusionsIntroduction of HPV testing resulted in a substantial number of women screened, and acceptance of self-sampling was high. Management of screen-positive women remained a challenge, particularly with Pap triage. Our results can inform other developing countries as they work to reach World Health Organization (WHO) elimination targets.

Indexed as

AdultEarly Detection of CancerFemaleHumansMiddle AgedNicaraguaPapillomaviridaePapillomavirus InfectionsUterine Cervical NeoplasmsCervical cancerFollow-upHPV testNicaraguaScreeningSelf-samplingTreatment

Identifiers

PMID32295562
PMCPMC7161152
OpenAlexW3016786174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.