Evidence map›Paper›PMID 32295543›Full record

ArticleBMC cancer2020

3'UTR polymorphism of Thymidylate Synthase gene increased the risk of persistence of pre-neoplastic cervical lesions.

Nayara Nascimento Toledo Silva, Ana Carolina Silva Santos, Verlândia Mendes Nogueira, Cláudia Martins Carneiro, Angélica Alves Lima

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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  6. Single Nucleotide Polymorphism in the 3' Untranslated Region ofTherapeutics and clinical risk management · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nayara Nascimento Toledo SilvaPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, Minas Gerais, 35400-000, Brazil. nayarants@gmail.com.
Ana Carolina Silva SantosPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Verlândia Mendes NogueiraCentro Estadual de Atenção Especializada (CEAE) de Itabirito, Rua Antônio Carlos, 202 - Praia, Itabirito, Minas Gerais, 35450-000, Brazil.
Cláudia Martins CarneiroPrograma de Pós-Graduação em Ciências Biológicas e Biotecnologia, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Angélica Alves LimaPrograma de Pós-Graduação em Ciências Farmacêuticas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, Minas Gerais, 35400-000, Brazil.
Universidade Federal de Ouro Preto · BR

Funding

Pró-Reitoria de Pesquisa e Pós-Graduação (PROPP), Universidade Federal de Ouro Preto 082017013Pró-Reitoria de Pesquisa e Pós-Graduação (PROPP), Universidade Federal de Ouro Preto 082017066
6 · The paper itself

Abstract

backgroundCervical cancer is caused by high-risk Human Papillomavirus (hr-HPV) infection associated with cofactors that has been analyzed as predictors of the remission or persistence of cytological abnormalities remission or persistence. These cofactors can be either environmental, epigenetic, or genetic. Polymorphism in genes of enzymes that act on one-carbon metabolism alter their activity and also may be associated with cervical carcinogenesis because they affect DNA synthesis and repair, and gene expression. Therefore, this study aimed to analyze the risk of persistence of pre-neoplastic cervical lesions according to genetic polymorphisms involved in one-carbon metabolism.

methodsOur sample consisted of 106 women, divided into two groups - Remission (n = 60), i.e., with the presence of pre-neoplastic lesions at first meeting (T

resultsWe observed no differences between the Remission and Persistence groups regarding the GRS. Also, there were no differences in the genotypic and allelic distribution of MTHFR C677T and MS A2756G polymorphisms. However, the risk of persistence was higher among women with the heterozygote genotype - ins/del [OR (IC95%): 3.22 (1.19-8.69), p = 0.021], or the polymorphic genotype - del/del [OR (IC95%): 6.50 (1.71-24.70), p = 0.006] of TS3'UTR.

conclusionsThe presence of the TS3'UTR polymorphism increased the risk of persistence of cervical abnormalities. This genetic variant could be a potential marker of cervical carcinogenesis and therefore assist the follow-up of women with persistent pre-neoplastic cervical lesions.

Indexed as

3' Untranslated Regions5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseAdultAgedDNA, ViralFemaleHumansMiddle AgedPapillomaviridaePapillomavirus InfectionsPolymorphism, Single NucleotidePrecancerous ConditionsThymidylate SynthaseUterine Cervical NeoplasmsYoung Adult3' Untranslated Regions5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseDNA, ViralMTR protein, humanThymidylate SynthaseTYMS protein, humanGenetic polymorphismsHPVPre-neoplastic cervical lesionsThymidylate synthaseTS3’UTR

Identifiers

PMID32295543
PMCPMC7161242
OpenAlexW3017089541

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.