Evidence map›Paper›PMID 32295531›Full record

Trial reportBMC nephrology2020

The effect of BCM guided dry weight assessment on short-term survival in Chinese hemodialysis patients : Primary results of a randomized trial - BOdy COmposition MOnitor (BOCOMO) study.

Li Liu, Yi Sun, Yuqing Chen, Jinsheng Xu, Ping Yuan, Yulan Shen, Shan Lin, Weiming Sun, Yingchun Ma, Jianwei Ren and 3 more

2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01509937 nacompletednot on this map

A Randomized Controlled Trial of Long Term Effect of BCM Guided Fluid Management in MHD Patients

TypeinterventionalSponsorPeking University First HospitalRan2013 to 2015Enrolled433ConditionsEnd Stage Renal DiseaseArmsbody bioimpedance spectroscopy device, Device
NCT06573567 nacompletednot on this mapstarted 2024, after this paper: background citation

Target Weight Guided by Bioimpedance Analysis in Hemodialysis Patients

TypeinterventionalSponsorCishan Hospital, Ministry of Health and WelfareRan2024 to 2026Enrolled50ConditionsHemodialysis ComplicationArmsBioimpedance, Control
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Volume Assessment in Patients Undergoing Long-Term Dialysis.Journal of the American Society of Nephrology : JASN · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Li LiuRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Yi SunDepartment of Nephrology, Capital Medical University Fuxing Hospital, Beijing, China.
Yuqing ChenRenal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Jinsheng XuDepartment of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Ping YuanNephrotic Blood Purification Center, Tianjin Third Central Hospital, Tianjin, China.
Yulan ShenDepartment of Nephrology, Beijing Miyun County Hospital, Beijing, China.
Shan LinDepartment of Nephrology, General Hospital of Tianjin Medical University, Tianjin, China.
Weiming SunDepartment of Nephrology, Beijing Shijitan Hospital, Beijing, China.
Yingchun MaDepartment of Nephrology, Beijing Boai Hospital, China Rehabilitation Research Center, Captain Medical University, Rehabilitation Medical College, Beijing, China.
Jianwei RenDepartment of Nephrology, Aviation General Hospital, Beijing, China.
Wenjun LiuDepartment of Nephrology, China Academy of Chinese Medical Sciences Guang'anmen Hospital, Beijing, China.
Jinghong LeiDepartment of Nephrology, Beijing Aerospace General Hospital, Beijing, China.
Li ZuoDepartment of Nephrology, Peking University People's Hospital, Beijing, China. zuoli@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLack of accurate and effective assessment tools of fluid status is one of the major challenges to reach proper dry weight (DW) in chronic hemodialysis (HD) population. The aim of this randomized study was to evaluate the effect of bioimpedance guided DW assessment on long-term outcomes in Chinese HD patients. Eligible patients were randomly assigned (1:1) to two groups in each center, the control group and body composition monitor (BCM) group. In the BCM group, DW has been evaluated by bioimpedance technic every 2 months during follow-up. The primary composite endpoint consisted of death, acute myocardial infarction, cerebral infarction, cerebral hemorrhage, and peripheral vascular disease.

methodsA total of 445 patients were recruited from 11 hemodialysis centers from Beijing, Tianjin and Shijiazhuang cities from Jan 1, 2013 to Dec 31, 2014. They were randomized into either BCM group or control group. All patients have been followed up for 1 year or until Dec 31, 2014 or censoring.

resultsAt baseline, there were no significant differences between two groups in terms of demographic parameters, dialysis vintage, percentage of vascular access, and comorbid conditions. At the end of the study, 18 (4.04%) patients had died (11 in control group and 7 in BCM group). Kaplan-Meier survival analysis showed no significant difference in survival rates between two groups (log-rank test P = 0.07). However, there was an increasing trend of survival rates in BCM group compared to the control group. In the multivariable Cox analysis, there was a nonsignificant trend toward less primary composite end points in the BCM group in the adjusted analysis, the hazard ratio was impressive (0.487, 95% CI 0.217-1.091, P = 0.08).

conclusionBioimpedance technic has been applied to assess fluid status for decades and has been proved to be a promising tool for clinical practice. Although short-term outcomes were not improved in the randomized, controlled trial, the ascending trend in survival has been observed. Further studies are needed to investigate the survival benefit of bioimpedance method in DW assessment in a larger sample with longer follow-up period.

trial registrationClinicalTrials.org, NCT01509937. Registered 13 January 2012.

Indexed as

Body CompositionElectric ImpedanceKidney Failure, ChronicRenal DialysisBody FluidsBody Weights and MeasuresChinaFemaleHumansLong Term Adverse EffectsMaleMiddle AgedMonitoring, PhysiologicSurvival AnalysisWater-Electrolyte BalanceBioimpedanceBody composition monitorDry weightHemodialysisHydration statusMortality

Identifiers

PMID32295531
PMCPMC7161118

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.