ArticleBMC neurology2020
Functional brain network mechanism of executive control dysfunction in temporal lobe epilepsy.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Salience network hub dysfunction is associated with cognitive impairment in self-limited epilepsy with centrotemporal spikes: An OPM-MEG study.Epilepsia open · 2026Article
- Multisensory Rhythmic Entrainment as a Mechanistic Framework for Modulating Prefrontal Network Stability in Focal Epilepsy.Brain sciences · 2025Article
- Task-Evoked Theta Oscillation Dysregulation Underlies Attention Network Deficits in Left Temporal Lobe Drug-Resistant Epilepsy.CNS neuroscience & therapeutics · 2025Article
- Narrative Review on Common Traits of Parkinson's Disease and Epilepsy.Journal of clinical medicine · 2025Review
- Frequency-band specific directed connectivity networks reveal functional disruptions and pathogenic patterns in temporal lobe epilepsy: a MEG study.Scientific reports · 2025Article
- Altered Effective Connectivity of the Attentional Network in Temporal Lobe Epilepsy with EEG Data.Bioengineering (Basel, Switzerland) · 2025Article
- Exploring the Impact of Declarative Learning on the Consolidation of Acquired Motor Skills Under Valence Feedback.Human brain mapping · 2025Article
- The network is more important than the node: stereo-EEG evidence of neurocognitive networks in epilepsy.Frontiers in network physiology · 2024Article
- A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young Mice Model.Marine drugs · 2023Article
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6 authors.
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Abstract
backgroundExecutive control dysfunction is observed in a sizable number of patients with temporal lobe epilepsy (TLE). Neural oscillations in the theta band are increasingly recognized as having a crucial role in executive control network. The purpose of this study was to investigate the alterations in the theta band in executive control network and explore the functional brain network mechanisms of executive control dysfunction in TLE patients.
methodsA total of 20 TLE patients and 20 matched healthy controls (HCs) were recruited in the present study. All participants were trained to perform the executive control task by attention network test while the scalp electroencephalogram (EEG) data were recorded. The resting state signals were collected from the EEG in the subjects with quiet and closed eyes conditions. Functional connectivity among EEGs in the executive control network and resting state network were respectively calculated.
resultsWe found the significant executive control impairment in the TLE group. Compared to the HCs, the TLE group showed significantly weaker functional connectivity among EEGs in the executive control network. Moreover, in the TLE group, we found that the functional connectivity was significantly positively correlated with accuracy and negatively correlated with EC_effect. In addition, the functional connectivity of the executive control network was significantly higher than that of the resting state network in the HCs. In the TLE group, however, there was no significant change in functional connectivity strengths between the executive control network and resting state network.
conclusionOur results indicate that the decreased functional connectivity in theta band may provide a potential mechanism for executive control deficits in TLE patients.
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