Evidence map›Paper›PMID 32295462›Full record

Trial reportInnate immunity2020

Aslam H Qureshi, Dong Liang, Jorge Canas, Jenaya Hooks, Samuel W Arrregui, Vijay Saxena, Robert Rooney, Vikki Nolan, Andrew L Schwaderer, David S Hains

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Innate immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Urinary tract infections in children.Nature reviews. Urology · 2026
    Review
  2. Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenicProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Aslam H QureshiDivision of Pediatric Nephrology, Department of Pediatrics, University of Tennessee Health Science Center, USA.
Dong LiangDepartment of Pediatrics, Indiana University School of Medicine, USA.
Jorge CanasDepartment of Pediatrics, Indiana University School of Medicine, USA.
Jenaya HooksDepartment of Pediatrics, Indiana University School of Medicine, USA.
Samuel W ArrreguiDepartment of Pediatrics, Indiana University School of Medicine, USA.
Vijay SaxenaDepartment of Pediatrics, Indiana University School of Medicine, USA.
Robert RooneyIntegrative Genomics Biorepository, Department of Pediatrics, University of Tennessee Health Science Center, USA.
Vikki NolanDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, USA.
Andrew L SchwadererDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, USA.
David S HainsDivision of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, USA.ORCID 0000-0001-6511-9561
Indiana University School of MedicineUniversity of Memphis · USUniversity of Tennessee Health Science Center · US

Funding

Genetic Regulation, Tubular Processing and Clinical Relevance of Collecting Duct alpha-Defensins 1-3R01DK117934 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI CINES, DOUGLAS BROCK, HAINS, DAVID SULLIVAN · 2018 to 2021
$2.3M
The interface between critical acid-base mediators and the renal bacterial defenseR01DK106286 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HAINS, DAVID SULLIVAN, SCHWADERER, ANDREW LAWRENCE · 2015 to 2018
$1.6M
Genetic Variations and Development of Vesicoureteral Reflux and SequelaeRC4DK090937 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HAINS, DAVID SULLIVAN, SCHWADERER, ANDREW LAWRENCE · 2010 to 2010
$1.5M
NIDDK NIH HHS R01 DK106286NIDDK NIH HHS R01 DK117934NIDDK NIH HHS RC4 DK090937
6 · The paper itself

Abstract

Urinary tract infections (UTI), associated with vesicoureteral reflux (VUR), can lead to chronic kidney disease. Genetic alterations in the innate immune defenses contribute to UTI risk. We investigated a novel gene, Dachsous Cadherin-Related 1 (

Indexed as

GenotypeAnimalsCadherin Related ProteinsCadherinsChildChild, PreschoolDNA Copy Number VariationsFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansInfantMaleMiceMice, Inbred C57BLCadherin Related ProteinsCadherinsDCHS1 protein, humanDNA CN variationspediatricsurinary tract infectionsvesicoureteral reflux

Identifiers

PMID32295462
PMCPMC7491237
OpenAlexW3016898884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.