Evidence map›Paper›PMID 32295382›Full record

ArticleAIDS research and human retroviruses2020

Impact of Early Antiretroviral Treatment Initiation on Performance of Cross-Sectional Incidence Assays.

Ethan Klock, George Mwinnya, Leigh Anne Eller, Reinaldo E Fernandez, Hannah Kibuuka, Sorachai Nitayaphan, Josphat Kosgei, Richard D Moore, Merlin Robb, Susan H Eshleman and 1 more

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Ethan KlockThe Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
George MwinnyaNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA.
Leigh Anne EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Reinaldo E FernandezThe Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hannah KibuukaMakerere University Walter Reed Project, Kampala, Uganda.
Sorachai NitayaphanArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Josphat KosgeiKenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Richard D MooreThe Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Merlin RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Susan H EshlemanThe Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Oliver LaeyendeckerNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA.
Johns Hopkins University · USNational Institute of Allergy and Infectious Diseases · USArmed Forces Research Institute of Medical Science · THHenry M. Jackson Foundation · USJackson Foundation · USJohns Hopkins Medicine · USMakerere University Walter Reed Project · UGWalter Reed Army Institute of Research · US

Funding

LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Laboratory and Statistical Development of Cross-Sectional HIV Incidence AssaysR01AI095068 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ESHLEMAN, SUSAN H · 2011 to 2021
$6.6M
NIAID NIH HHS R01 AI095068NIAID NIH HHS UM1 AI068613
6 · The paper itself

Abstract

Antiretroviral therapy (ART) can impact assays used for cross-sectional HIV incidence testing, causing inaccurate HIV incidence estimates. We evaluated the relationship between the timing of ART initiation and the performance of two serologic HIV incidence assays. We analyzed 302 samples from 55 individuals from the RV217 cohort (Early Capture HIV Cohort Study). Participants were grouped by ART start time: ART started <1 year after infection (

Indexed as

AdolescentAdultAntibody AffinityAnti-Retroviral AgentsCohort StudiesCross-Sectional StudiesFemaleHIV-1HIV AntibodiesHIV InfectionsHumansIncidenceMaleMass ScreeningSustained Virologic ResponseTime FactorsAnti-Retroviral AgentsHIV Antibodiesantibody avidityantiretroviral therapyHIV incidencelimiting antigen avidity

Identifiers

PMID32295382
PMCPMC7398433
OpenAlexW3016769372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.