ArticleAntibiotics (Basel, Switzerland)2020
Polyphasic Validation of a Nisin-Biogel to Control Canine Periodontal Disease.
Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of dietary antimicrobial peptides on growth performance, antioxidant capacity, immune response and disease resistance of juvenile Nile tilapia (Frontiers in physiology · 2026Article
- Evaluation of Biofilm Inhibitory Activity of Probiotics and Postbiotics Using In Vitro Biofilm Model of Canine Periodontal Disease.Microorganisms · 2025Article
- Antimicrobial, Antioxidant and Anti-Inflammatory Activities of the Mucus of the Tropical Sea SlugMolecules (Basel, Switzerland) · 2024Article
- Phenotypic Characterization of OralLife (Basel, Switzerland) · 2023Article
- In Vivo Effect of a Nisin-Biogel on the Antimicrobial and Virulence Signatures of Canine OralAntibiotics (Basel, Switzerland) · 2023Article
- In Vivo Evaluation of the Efficacy of a Nisin-Biogel as a New Approach for Canine Periodontal Disease Control.Pharmaceutics · 2022Article
- Revisiting Periodontal Disease in Dogs: How to Manage This New Old Problem?Antibiotics (Basel, Switzerland) · 2022Review
- Bromelain and Nisin: The Natural Antimicrobials with High Potential in Biomedicine.Pharmaceutics · 2021Review
- Bacteriocins from Lactic Acid Bacteria. A Powerful Alternative as Antimicrobials, Probiotics, and Immunomodulators in Veterinary Medicine.Animals : an open access journal from MDPI · 2021Review
- Influence of the dental topical application of a nisin-biogel in the oral microbiome of dogs: a pilot study.PeerJ · 2021Article
- A polymicrobial biofilm model for testing the antimicrobial potential of a nisin-biogel for canine periodontal disease control.BMC veterinary research · 2020Article
- Periodontal pathogens promote cancer aggressivity via TLR/MyD88 triggered activation of Integrin/FAK signaling that is therapeutically reversible by a probiotic bacteriocin.PLoS pathogens · 2020Article
- New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action.Antibiotics (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPeriodontal disease (PD) is a highly prevalent inflammatory disease in dogs. This disease is initiated by a polymicrobial biofilm on the teeth surface, whose control includes its prevention and removal. Recently, it was shown that nisin displays antimicrobial activity against canine PD-related bacteria. Moreover, guar gum biogel has shown to be a promising topical delivery system for nisin.
methodsIn this study we aimed to evaluate the antimicrobial activity of the nisin-biogel in the presence of canine saliva and after a 24-month storage, at different conditions, using a canine oral enterococci collection. We also studied the nisin-biogel cytotoxicity using a Vero cell line and canine primary intestinal fibroblasts.
resultsThe presence of saliva hampers nisin-biogel antimicrobial activity, and higher nisin concentrations were required for an effective activity. A significant reduction (
conclusionsOur results confirmed the potential of the nisin-biogel for canine PD control, supporting the development of an in vivo clinical trial.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.