Evidence map›Paper›PMID 32295063›Full record

ArticleCells2020

The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in

Bahjat F Marayati, James F Tucker, David A De La Cerda, Tien-Chi Hou, Rong Chen, Tomoyasu Sugiyama, James B Pease, Ke Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. The Fission Yeast Mating-Type Switching Motto: "One-for-Two" and "Two-for-One".Microbiology and molecular biology reviews : MMBR · 2023
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Bahjat F MarayatiDepartment of Biology, Center for Molecular Signaling, Wake Forest University, Winston-Salem, NC 27109, USA.
James F TuckerDepartment of Biology, Center for Molecular Signaling, Wake Forest University, Winston-Salem, NC 27109, USA.
David A De La CerdaDepartment of Biology, Center for Molecular Signaling, Wake Forest University, Winston-Salem, NC 27109, USA.
Tien-Chi HouDepartment of Biology, Center for Molecular Signaling, Wake Forest University, Winston-Salem, NC 27109, USA.
Rong ChenPhysiology and pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Tomoyasu SugiyamaSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
James B PeaseDepartment of Biology, Center for Molecular Signaling, Wake Forest University, Winston-Salem, NC 27109, USA.
Ke ZhangDepartment of Biology, Center for Molecular Signaling, Wake Forest University, Winston-Salem, NC 27109, USA.
Wake Forest University · USShanghaiTech University · CN

Funding

RGS2 regulation of D2 receptor signalingR01DA042862 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHEN, RONG · 2017 to 2021
$1.5M
Request fund to purchase equipment (the BioComp gradient primer) to supplement R15 GM139107-01R15GM139107 · NIGMS · WAKE FOREST UNIVERSITY · PI REID, KE ZHANG · 2020 to 2022
$469k
Determination of a Novel Epigenetic Silencing MechanismR15GM119105 · NIGMS · WAKE FOREST UNIVERSITY · PI REID, KE ZHANG · 2016 to 2016
$420k
NIDA NIH HHS R01 DA042862NIGMS NIH HHS R15 GM119105NIGMS NIH HHS R15 GM139107
6 · The paper itself

Abstract

In eukaryotes, heterochromatin plays a critical role in organismal development and cell fate acquisition, through regulating gene expression. The evolutionarily conserved lysine-specific demethylases, Lsd1 and Lsd2, remove mono- and dimethylation on histone H3, serving complex roles in gene expression. In the fission yeast

Indexed as

HeterochromatinHistone DemethylasesSchizosaccharomycesHeterochromatinHistone Demethylasesgene silencingH3K9me2heterochromatinLsd1Lsd2lysine demethylase

Identifiers

PMID32295063
PMCPMC7226997
OpenAlexW3015399799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.