Evidence map›Paper›PMID 32294932›Full record

ArticleBiomedicines2020

A Non-Coding RNA Landscape of Bronchial Epitheliums of Lung Cancer Patients.

Yanli Lin, Van Holden, Pushpawallie Dhilipkannah, Janaki Deepak, Nevins W Todd, Feng Jiang

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  6. Review
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  8. Review
  9. Article
  10. Article
  11. Microbiota Biomarkers for Lung Cancer.Diagnostics (Basel, Switzerland) · 2021
    Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yanli LinDepartments of Pathology, University of Maryland School of Medicine, 10 S. Pine St. Baltimore, MD 21201, USA.
Van HoldenDepartment of Medicine, University of Maryland School of Medicine, 22 S. Greene St. Baltimore, MD 21201, USA.
Pushpawallie DhilipkannahDepartments of Pathology, University of Maryland School of Medicine, 10 S. Pine St. Baltimore, MD 21201, USA.
Janaki DeepakDepartment of Medicine, University of Maryland School of Medicine, 22 S. Greene St. Baltimore, MD 21201, USA.
Nevins W ToddDepartment of Medicine, University of Maryland School of Medicine, 22 S. Greene St. Baltimore, MD 21201, USA.
Feng JiangDepartment of Medicine, University of Maryland School of Medicine, 22 S. Greene St. Baltimore, MD 21201, USA.
University of Maryland, Baltimore · US

Funding

A diagnostic model for malignant pulmonary nodulesR21CA240556 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI JIANG, FENG · 2019 to 2020
$370k
NCI NIH HHS 1R21CA240556
6 · The paper itself

Abstract

We propose to systematically identify a non-coding RNA (ncRNA) profile of exfoliated bronchial epitheliums of sputum from lung cancer patients. Bronchial epithelial cells enriched from sputum of 32 lung cancer patients and 33 cancer-free smokers were analyzed by next-generation sequencing to comprehensively characterize the ncRNA profiles. In addition, 108 miRNAs, 88 small nucleolar RNAs, 13 piwi-interacting RNAs, 6 transfer RNAs, 4 ribosomal RNAs, 19 small nuclear RNAs, and 25 long-noncoding (lnc) RNAs displayed a significantly different level in bronchial epitheliums of sputum of lung cancer patients versus cancer-free smokers (all <0.001). PCR analysis confirmed their different expression levels in the sputum specimens. A high expression of SNHG9, an lncRNA, was validated in 78 lung tumor tissues, and the expression was inversely associated with overall survival of lung cancer patients (

Indexed as

and biomarkersfunctionlung cancernon-coding RNAssputum

Identifiers

PMID32294932
PMCPMC7235744
OpenAlexW3015791145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.