Evidence map›Paper›PMID 32294655›Full record

ArticleOncology2020

Preoperative Radiotherapy Leads to Significant Differences in the Plasma Protein Profile of Rectal Cancer Patients.

Matilda Holm, Sakari Joenväärä, Mayank Saraswat, Tiialotta Tohmola, Ari Ristimäki, Risto Renkonen, Caj Haglund

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Matilda HolmDepartment of Surgery, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, matilda.holm@helsinki.fi.
Sakari JoenvääräTransplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Mayank SaraswatDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Tiialotta TohmolaTransplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Ari RistimäkiDepartment of Pathology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Risto RenkonenTransplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Caj HaglundDepartment of Surgery, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Helsinki University Hospital · FIUniversity of Helsinki · FIMayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionColorectal cancer (CRC) is the third most common cancer worldwide, accounting for 10% of the global cancer burden. Rectal cancer accounts for around 30% of CRC cases, and patients with resectable rectal cancer are often given preoperative radiotherapy (PRT) to reduce the rate of local recurrence. The human plasma proteome is an exceptionally complex proteome and ideal to study due to its ability to reflect the presence of diseases such as cancer and the ease of obtaining blood samples. Previous proteomic studies involving rectal cancer patients have mostly focused on the identification of proteins involved in resistance to radiotherapy.

objectiveThe aim of this study was to investigate the overall effects of PRT on plasma protein expression in rectal cancer patients, as there is a lack of such studies.

methodsHere, we have used mass spectrometry and subsequent statistical analyses to analyze the plasma samples of 30 rectal cancer patients according to PRT status (positive or negative) and tumor stage (II or III). RESULTS AND

conclusionsWe discovered 42 proteins whose levels differed significantly between stage II and III rectal cancer patients who did or did not receive PRT. This study shows that PRT, although localized to the pelvis, leads to measurable, tumor stage-specific changes in plasma protein expression. Future studies of plasma proteins should, when relevant, take this into account and be aware of the widespread effects that PRT has on the plasma proteome.

Indexed as

Preoperative CareBlood ProteinsChromatography, LiquidFinlandHospitals, UniversityHumansMass SpectrometryNeoplasm StagingPilot ProjectsProteomeProteomicsRectal NeoplasmsRetrospective StudiesBlood ProteinsProteomeColorectal cancerMass spectrometryPlasmaPreoperative radiotherapyProteomics

Identifiers

PMID32294655
PMCPMC7384342
OpenAlexW3015752272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.