Evidence map›Paper›PMID 32294495›Full record

ArticleInternational journal of antimicrobial agents2020

Chloroquine as a prophylactic agent against COVID-19?

Mathieu Gendrot, Emilie Javelle, Axelle Clerc, Hélène Savini, Bruno Pradines

Registry-linked trialAbstract readEditorial
In one paragraph

Article in International journal of antimicrobial agents, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04443270 (Efficacy of Chloroquine Phosphate Prophylactic Use in First-line Health Personnel Exposed to COVID-19 Patients), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04443270 phase1unknown statusnot on this map

Efficacy of Chloroquine Phosphate Prophylactic Use in First-line Health Personnel Exposed to COVID-19 Patients

TypeinterventionalSponsorCMN "20 de Noviembre"Ran2020 to 2021Enrolled200ConditionsCOVID-19ArmsChloroquine phosphate
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19.The Cochrane database of systematic reviews · 2021
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Chloroquine commonly induces hormetic dose responses.The Science of the total environment · 2021
    Article
  9. Article
  10. Article
  11. Ototoxicity prevention during the SARS-CoV-2 (COVID-19) emergency.Journal of global antimicrobial resistance · 2020
    Article
  12. Article
  13. Article
  14. Dual function of sialic acid in gastrointestinal SARS-CoV-2 infection.Environmental toxicology and pharmacology · 2020
    Review
  15. Natural history of COVID-19 and current knowledge on treatment therapeutic options.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
    Review
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mathieu GendrotUnité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France; Aix Marseille Univ, IRD, SSA, AP-HM, VITROME, Marseille, France; IHU Méditerranée Infection, Marseille, France.
Emilie JavelleAix Marseille Univ, IRD, SSA, AP-HM, VITROME, Marseille, France; IHU Méditerranée Infection, Marseille, France; Service des Maladies Infectieuses, Hôpital d'Instruction des Armées Laveran, Marseille, France.
Axelle ClercService des Maladies Infectieuses, Hôpital d'Instruction des Armées Laveran, Marseille, France.
Hélène SaviniAix Marseille Univ, IRD, SSA, AP-HM, VITROME, Marseille, France; Service des Maladies Infectieuses, Hôpital d'Instruction des Armées Laveran, Marseille, France.
Bruno PradinesUnité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, Marseille, France; Aix Marseille Univ, IRD, SSA, AP-HM, VITROME, Marseille, France; IHU Méditerranée Infection, Marseille, France; Centre National de Référence du Paludisme, Marseille, France. Electronic address: bruno.pradines@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntimalarialsAntiviral AgentsAzithromycinBetacoronavirusChlorocebus aethiopsChloroquineCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentDrug Therapy, CombinationHumansHydroxychloroquinePandemicsPneumonia, ViralPre-Exposure ProphylaxisAntimalarialsAntiviral AgentsAzithromycinChloroquineHydroxychloroquine

Identifiers

PMID32294495
PMCPMC7152897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.