Evidence map›Paper›PMID 32294437›Full record

ArticleCell reports2020

BCR-Induced Ca

Corbett T Berry, Xiaohong Liu, Arpita Myles, Satabdi Nandi, Youhai H Chen, Uri Hershberg, Igor E Brodsky, Michael P Cancro, Christopher J Lengner, Michael J May and 1 more

Abstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. A guide to B cell metabolism.Nature reviews. Immunology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. EfficientImmune network · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Corbett T BerryDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; School of Biomedical Engineering, Science and Health Systems, Drexel University, PA 19104, USA.
Xiaohong LiuDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Arpita MylesDepartment of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Satabdi NandiDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Youhai H ChenDepartment of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Uri HershbergSchool of Biomedical Engineering, Science and Health Systems, Drexel University, PA 19104, USA; Department of Human Biology, Faculty of Sciences, University of Haifa, Haifa 3498838, Israel.
Igor E BrodskyDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael P CancroDepartment of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christopher J LengnerDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; University of Pennsylvania Institute for Regenerative Medicine, Philadelphia, PA 19104, USA.
Michael J MayDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bruce D FreedmanDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bruce@vet.upenn.edu.

Funding

Novel Mechanisms of Calcium Signaling in B lymphocytesR01AI060921 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2005 to 2014
$3.9M
Defining the non-apoptotic role of Caspase-8 activity in anti-bacterial immune defenseR01AI128530 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2017 to 2021
$2.0M
Endothelial Cell-Intrinsic Non-Canonical NF-kB in Chronic inflammationR01AR066567 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MAY, MICHAEL J · 2017 to 2021
$1.9M
Targeting NF-kB in AtherosclerosisR01HL096642 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MAY, MICHAEL J · 2011 to 2014
$1.6M
Calcium Regulation of NF-kB Activation in LymphocytesR56AI125415 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D, MAY, MICHAEL J · 2016 to 2016
$576k
Novel Mechanisms of c-Rel Dependent Thymic Regulatory T Cell DevelopmentR21AI142162 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI FREEDMAN, BRUCE D · 2019 to 2020
$445k
NHLBI NIH HHS R01 HL096642NIAID NIH HHS R01 AI060921NIAID NIH HHS R01 AI128530NIAID NIH HHS R21 AI142162NIAID NIH HHS R56 AI125415NIAMS NIH HHS R01 AR066567
6 · The paper itself

Abstract

B cell receptor (BCR) engagement induces naive B cells to differentiate and perform critical immune-regulatory functions. Acquisition of functional specificity requires that a cell survive, enter the cell cycle, and proliferate. We establish that quantitatively distinct Ca

Indexed as

AnimalsApoptosisB-LymphocytesCalciumCell CycleCell DifferentiationCell ProliferationCell SurvivalLymphocyte ActivationMaleMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLNFATC Transcription FactorsNF-kappa BPrecursor Cells, B-LymphoidCalciumMechanistic Target of Rapamycin Complex 1NFATC Transcription FactorsNF-kappa BReceptors, Antigen, B-CellapoptosisBcl-xLCD40c-Mycc-RelmTORC1NFATnuclear factor kappa BOrai1STIM1

Identifiers

PMID32294437
PMCPMC7301411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.