Evidence map›Paper›PMID 32294414›Full record

ReviewTrends in genetics : TIG2020

New Solutions to Old Problems: Molecular Mechanisms of Meiotic Crossover Control.

Gerald R Smith, Mridula Nambiar

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Evaluation and Aggregation of Active Module Identification Algorithms.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Genetic control of meiosis surveillance mechanisms in mammals.Frontiers in cell and developmental biology · 2023
    Review
  10. Article
  11. Review
  12. Review
  13. From Microscopy to Nanoscopy: Defining anFrontiers in plant science · 2021
    Review
  14. Meiotic Crossover Patterning.Frontiers in cell and developmental biology · 2021
    Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gerald R SmithDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: gsmith@fredhutch.org.
Mridula NambiarDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Biology, Indian Institute of Science Education and Research, Pune, India.

Funding

Molecular analysis of genetic recombination and DNA break repairR35GM118120 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SMITH, GERALD R · 2016 to 2025
$9.3M
NIGMS NIH HHS R35 GM118120
6 · The paper itself

Abstract

During scientific investigations, the explanation of remarkably interesting phenomena must often await development of new methods or accrual of new observations that in retrospect can lead to lucid answers to the initial problem. A case in point is the control of genetic recombination during meiosis, which leads to crossovers between chromosomes critical for production of healthy offspring. Crossovers must be properly placed along meiotic chromosomes for their accurate segregation. Here, we review observations on two aspects of meiotic crossover control - crossover interference and repression of crossovers near centromeres, both observed more than 85 years ago. Only recently have relatively simple molecular mechanisms for these phenomena become clear through advances in both methods and understanding the molecular basis of meiotic recombination.

Indexed as

CentromereChromosome SegregationCrossing Over, GeneticDNA Breaks, Double-StrandedHomologous RecombinationMeiosiscentromeric repressioncrossover interferenceDNA break hotspot clustersheterochromatinlinear element proteinssister chromatid cohesins

Identifiers

PMID32294414
PMCPMC7162993

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.