Evidence map›Paper›PMID 32294409›Full record

ArticleImmunity2020

Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants.

Lucy Helen Jackson-Jones, Peter Smith, Jordan Raymond Portman, Marlène Sophie Magalhaes, Katie Jude Mylonas, Matthieu Marie Vermeren, Mark Nixon, Beth Emily Pollot Henderson, Ross Dobie, Sonja Vermeren and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Propionate Induces Energy Expenditure via Browning in Mesenteric Adipose Tissue.The Journal of clinical endocrinology and metabolism · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Tissue adhesion after surgical interventions (Review).Experimental and therapeutic medicine · 2025
    Review
  12. Overcoming immunotherapy resistance in hepatocellular carcinoma by targeting myeloid IL-8/CXCR2 signaling.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lucy Helen Jackson-JonesCentre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK; Division of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK. Electronic address: l.jackson-jones@lancaster.ac.uk.
Peter SmithCentre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Jordan Raymond PortmanCentre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Marlène Sophie MagalhaesCentre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Katie Jude MylonasCentre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK; Centre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Matthieu Marie VermerenCentre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Mark NixonCentre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Beth Emily Pollot HendersonCentre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Ross DobieCentre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Sonja VermerenCentre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Laura DenbyCentre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Neil Cowan HendersonCentre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Damian James MoleCentre for Inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Cécile BénézechCentre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK. Electronic address: cbenezec@ed.ac.uk.
University of Edinburgh · GBCentre for Inflammation Research · GB

Funding

British Heart Foundation RE/18/5/34216Medical Research Council MR/M011542/1Medical Research Council MR/P008887/1Medical Research Council MR/S008020/1Wellcome TrustWellcome Trust 103749Wellcome Trust 213697/Z/18/Z
6 · The paper itself

Abstract

The omentum is a visceral adipose tissue rich in fat-associated lymphoid clusters (FALCs) that collects peritoneal contaminants and provides a first layer of immunological defense within the abdomen. Here, we investigated the mechanisms that mediate the capture of peritoneal contaminants during peritonitis. Single-cell RNA sequencing and spatial analysis of omental stromal cells revealed that the surface of FALCs were covered by CXCL1

Indexed as

Acute DiseaseAnimalsAppendicitisCell CommunicationChemokine CXCL1Epithelial CellsEpitheliumEscherichia coliExtracellular TrapsFemaleGene ExpressionHumansLymphocytesMiceMice, Inbred C57BLMice, KnockoutChemokine CXCL1Cxcl1 protein, mousepeptidylarginine deiminase 4, mouseProtein-Arginine Deiminase Type 4ZymosanCXCL1FALCmesotheliumNETsneutrophilomentumperitonitisscRNA-seqstroma

Identifiers

PMID32294409
PMCPMC7156918
OpenAlexW3011357992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.