Evidence map›Paper›PMID 32293901›Full record

ArticleThe journal of physical chemistry letters2020

Peptide Side-COOH Groups Have Two Distinct Conformations under Biorelevant Conditions.

Oleksandr O Sofronov, Giulia Giubertoni, Alberto Pérez de Alba Ortíz, Bernd Ensing, Huib J Bakker

Open access · hybridAbstract read
In one paragraph

Article in The journal of physical chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. HumanACS catalysis · 2023
    Article
  6. Best Practices in Constant pH MD Simulations: Accuracy and Sampling.Journal of chemical theory and computation · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Oleksandr O SofronovAMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7744-6404
Giulia GiubertoniAMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3417-4987
Alberto Pérez de Alba OrtízAmsterdam Center for Multiscale Modeling and Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.
Bernd EnsingAmsterdam Center for Multiscale Modeling and Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4913-3571
Huib J BakkerAMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1564-5314
Institute for Atomic and Molecular Physics · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The carboxyl (COOH) side chain groups of amino acids, such as aspartic acid, play an important role in biochemical processes, including enzymatic proton transport. In many theoretical studies, it was found that the (bio)chemical reactivity of the carboxyl group strongly depends on the conformation of this group. Interestingly, up to now there has been no experimental investigation of the geometry and the stability of different COOH conformers under biorelevant conditions. Here, we investigate the conformational isomerism of the side chain COOH group of

Indexed as

AmidesIsomerismModels, MolecularMolecular ConformationPeptidesSpectrophotometry, InfraredAmidesPeptides

Identifiers

PMID32293901
PMCPMC7212517
OpenAlexW3016132239

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.