Evidence map›Paper›PMID 32293873›Full record

ArticleJournal of the American Chemical Society2020

Photoactivatable Glycolipid Probes for Identifying Mycolate-Protein Interactions in Live Mycobacteria.

Herbert W Kavunja, Kyle J Biegas, Nicholas Banahene, Jessica A Stewart, Brent F Piligian, Jessica M Groenevelt, Caralyn E Sein, Yasu S Morita, Michael Niederweis, M Sloan Siegrist and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 65 citations in OpenAlex.

  1. Structure, assembly, and mechanism of the MmpL family of transporters.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Review
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  9. Trehalose dimycolate inhibits phagosome maturation and promotes intracellularProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Exploiting thioether reactivity to label mycobacterial glycans.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Lipid probes to study ion channels.Current opinion in chemical biology · 2025
    Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Herbert W KavunjaDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.
Kyle J BiegasDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.
Nicholas BanaheneDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.
Jessica A StewartDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.
Brent F PiligianDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.
Jessica M GroeneveltDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.
Caralyn E SeinDepartment of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003, United States.
Yasu S MoritaDepartment of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003, United States.
Michael NiederweisDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
M Sloan SiegristDepartment of Microbiology, University of Massachusetts, Amherst, Massachusetts 01003, United States.
Benjamin M SwartsDepartment of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.ORCID 0000-0001-8402-359X
Central Michigan University · USUniversity of Massachusetts Amherst · USUniversity of Alabama at Birmingham · US

Funding

The necrosis-inducing toxin of Mycobacterium tuberculosisR01AI121354 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NIEDERWEIS, MICHAEL · 2016 to 2020
$2.5M
Chemical detection of Mycobacterium tuberculosis growth and antibiotic response during infectionDP2AI138238 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI SIEGRIST, MARY SLOAN · 2017 to 2017
$2.3M
Spatial organization of mycobacterial cell wall biosynthesisR21AI144748 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MORITA, YASU S, SIEGRIST, MARY SLOAN · 2019 to 2020
$423k
Membrane domain dynamics in Mycobacterium tuberculosisR03AI140259 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MORITA, YASU S · 2018 to 2019
$160k
NIAID NIH HHS DP2 AI138238NIAID NIH HHS R01 AI121354NIAID NIH HHS R03 AI140259NIAID NIH HHS R21 AI144748
6 · The paper itself

Abstract

Mycobacteria have a distinctive glycolipid-rich outer membrane, the mycomembrane, which is a critical target for tuberculosis drug development. However, proteins that associate with the mycomembrane, or that are involved in its metabolism and host interactions, are not well-characterized. To facilitate the study of mycomembrane-related proteins, we developed photoactivatable trehalose monomycolate analogues that metabolically incorporate into the mycomembrane in live mycobacteria, enabling

Indexed as

Click ChemistryGlycolipidsHumansMycobacteriumProteinsGlycolipidsProteins

Identifiers

PMID32293873
PMCPMC7949286
OpenAlexW3015726667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.