Evidence map›Paper›PMID 32293864›Full record

ArticleACS chemical biology2020

Asymmetric Total Synthesis of Mycobacterial Diacyl Trehaloses Demonstrates a Role for Lipid Structure in Immunogenicity.

Mira Holzheimer, Josephine F Reijneveld, Alexandrea K Ramnarine, Georgios Misiakos, David C Young, Eri Ishikawa, Tan-Yun Cheng, Sho Yamasaki, D Branch Moody, Ildiko Van Rhijn and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Asymmetric Total Synthesis and Structural Revision of DATAngewandte Chemie (International ed. in English) · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Mira HolzheimerStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.ORCID 0000-0003-2157-0136
Josephine F ReijneveldStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
Alexandrea K RamnarineBrigham and Women's Hospital Division of Rheumatology, Immunology and Allergy and Harvard Medical School, Boston, Massachusetts 02115, United States.
Georgios MisiakosStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
David C YoungBrigham and Women's Hospital Division of Rheumatology, Immunology and Allergy and Harvard Medical School, Boston, Massachusetts 02115, United States.
Eri IshikawaDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Tan-Yun ChengBrigham and Women's Hospital Division of Rheumatology, Immunology and Allergy and Harvard Medical School, Boston, Massachusetts 02115, United States.
Sho YamasakiDepartment of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
D Branch MoodyBrigham and Women's Hospital Division of Rheumatology, Immunology and Allergy and Harvard Medical School, Boston, Massachusetts 02115, United States.
Ildiko Van RhijnBrigham and Women's Hospital Division of Rheumatology, Immunology and Allergy and Harvard Medical School, Boston, Massachusetts 02115, United States.
Adriaan J MinnaardStratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.ORCID 0000-0002-5966-1300
Brigham and Women's Hospital · USUniversity of Groningen · NLThe University of Osaka · JP

Funding

Metabolomics Core U19AI111224 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MURRAY, MEGAN, MURRAY, MEGAN B · 2015 to 2021
$20.4M
T cell response to CDI-restricted lipids in tuberculosisR01AI049313 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2001 to 2025
$10.6M
NIAID NIH HHS R01 AI049313NIAID NIH HHS U19 AI111224
6 · The paper itself

Abstract

The first asymmetric total synthesis of three structures proposed for mycobacterial diacyl trehaloses, DAT

Indexed as

AnimalsChromatography, LiquidGlycolipidsHumansLectins, C-TypeMass SpectrometryMembrane ProteinsMiceMolecular StructureMycobacterium tuberculosisProtein BindingReceptors, ImmunologicStereoisomerismTrehaloseCLEC4D protein, humanClecsf8 protein, mouseGlycolipidsLectins, C-TypeMembrane ProteinsReceptors, ImmunologicTrehalose

Identifiers

PMID32293864
PMCPMC7372558
OpenAlexW3015884046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.