ArticleJBRA assisted reproduction2020
Correlation between morphokinetic parameters and standard morphological assessment: what can we predict from early embryo development? A time-lapse-based experiment with 2085 blastocysts.
Article in JBRA assisted reproduction, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Abnormal cleavage patterns in equine in vitro-produced embryos lead to higher early pregnancy loss.Equine veterinary journal · 2026Article
- A predictive model for high-quality blastocyst formation using Day 3 morphological scores in women of advanced maternal age.BMC pregnancy and childbirth · 2026Article
- When Fertilization Is Not Enough: Maternal-Zygotic Transition as a Determinant of Embryo Competence in IVF.International journal of molecular sciences · 2026Review
- The Relationship Between Abnormal Morphokinetic Embryos, Genetic Testing Results, and Clinical Outcomes.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
- Comparison of clinical outcomes for different morphological scores of D5 and D6 blastocysts in the frozen-thawed cycle.BMC pregnancy and childbirth · 2023Article
- Zygote Diameter and Total Cytoplasmic Volume as Useful Predictive Tools of Blastocyst Quality.Geburtshilfe und Frauenheilkunde · 2023Article
- Development of a dynamic machine learning algorithm to predict clinical pregnancy and live birth rate with embryo morphokinetics.F&S reports · 2022Article
- High anti-Müllerian hormone levels might not reflect the likelihood of clinical pregnancy rate in IVF/ICSI treatment.JBRA assisted reproduction · 2021Article
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Authors and funding
8 authors.
Funding
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Abstract
objectivesTo evaluate the association between morphology grading and morphokinetic parameters in blastocyst stage embryos cultured in a time-lapse system.
methodsThis retrospective cohort study included patients offered fertility treatment with autologous oocytes in our clinic between October 2017 and May 2019 using a time-lapse system. The embryos were morphologically graded according to the criteria developed by Gardner and Schoolcraft and their morphokinetic parameters were recorded.
resultsOur results indicated that the time of pronuclei fading (tPNf), time to cleavage into two (t2), four (t4), and eight (t8) cells, and time to start of blastulation (tB) were significantly different according to the morphological quality of the blastocysts formed. In the early development stage, tPNf, t2 and t4 differed between good (AA, AB, BA, BB) and poor (CC) quality potential blastocysts. The 8-cell stage time separated embryos graded as AA blastocysts in terms of morphology from embryos graded as BB. Earlier tB correlated with higher quality embryos (AA, AB, BA).
conclusionOur results showed that the first kinetic parameters (tPNf, t2, and t4) distinguished top-graded from low-graded blastocysts. Between top-graded blastocysts, t8 separated BB blastocysts from AA blastocysts. And finally, tB also told apart BB blastocysts from AA, AB, and BA blastocysts. These time-related parameters may be applied even in centers without time-lapse systems.
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