ArticleInvestigative ophthalmology & visual science2020
Age-Related Changes to the Three-Dimensional Full Shape of the Isolated Human Crystalline Lens.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
- Evaluation of the crystalline lens diameter using swept-source optical coherence tomography.BMJ open ophthalmology · 2026Article
- Crystalline lens geometry from a clinical OCT-based biometer in pre-cataract surgery patients.Research square · 2026Article
- Impact of Age-Related Changes in Lens Shape on the Increased Risk of Posterior Capsule Opacification Observed in Pediatric Cataract Patients.Translational vision science & technology · 2026Article
- Correlation of the crystalline lens thickness and ocular parameters in young and middle-aged myopes grouped by axial length.BMC ophthalmology · 2025Article
- In vivo assessment of multifocal contact lens fitting using anterior segment optical coherence tomography.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2025Article
- Crystalline lens power and astigmatism calculation in myopia by swept-source optical coherence tomography: A pilot study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Unveiling the Mysteries of the Chinese lens zonule balance tension: A statistical analysis.Heliyon · 2024Article
- Age dependence of the average refractive index of the isolated human crystalline lens.Biomedical optics express · 2024Article
- Cationic-motif-modified exosomes for mRNA delivery to retinal photoreceptors.Journal of materials chemistry. B · 2024Article
- Functional effects of the spatial-varying lens mechanical properties in accommodation.JPhys photonics · 2024Article
- Femtosecond Laser Cutting of Human Crystalline Lens Capsule and Decellularization for Corneal Endothelial Bioengineering.Bioengineering (Basel, Switzerland) · 2024Article
- 3D visualization of cellular and molecular distributions in human crystalline lenses at different ages.American journal of translational research · 2024Article
- Age-related changes in geometry and transparency of human crystalline lens revealed by optical signal discontinuity zones in swept-source OCT images.Eye and vision (London, England) · 2023Article
- Estimation of the full shape of the crystalline lens from OCT: validation using stretched donor lenses.Biomedical optics express · 2023Article
- The Role of Oxidative Stress in the Aging Eye.Life (Basel, Switzerland) · 2023Review
- Estimation of the full shape of the crystalline lensBiomedical optics express · 2023Article
- The growth and shape of the eyeball and crystalline lens in utero documented by fetal MR imaging.Heliyon · 2023Article
- Comparing low-coherence interferometry and A-scan ultrasonography in measuring ocular axial dimensions in young rhesus monkeys.Experimental eye research · 2022Article
- Prediction of Subjective Refraction From Anterior Corneal Surface, Eye Lengths, and Age Using Machine Learning Algorithms.Translational vision science & technology · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
Purpose: Studying the full shape crystalline lens geometry is important to understand the changes undergone by the crystalline lens leading to presbyopia, cataract, or failure of emmetropization, and to aid in the design and selection of intraocular lenses and new strategies for correction. We used custom-developed three-dimensional (3-D) quantitative optical coherence tomography (OCT) to study age-related changes in the full shape of the isolated human crystalline lens. Methods: A total of 103 ex vivo human isolated lenses from 87 subjects (age range, 0-56 years) were imaged using a 3-D spectral-domain OCT system. Lens models, constructed after segmentation of the surfaces and distortion correction, were used to automatically quantify central geometric parameters (lens thickness, radii of curvatures, and asphericities of anterior and posterior surfaces) and full shape parameters (lens volume, surface area, diameter, and equatorial plane position). Age-dependencies of these parameters were studied. Results: Most of the measured parameters showed a biphasic behavior, statistically significantly increasing (radii of curvature, lens volume, surface area, diameter) or decreasing (asphericities, lens thickness) very fast in the first two decades of life, followed by a slow but significant increase after age 20 years (for all the parameters except for the posterior surface asphericity and the equatorial plane position, that remained constant). Conclusions: Three-dimensional quantitative OCT allowed us to study the age-dependency of geometric parameters of the full isolated human crystalline lens. We found that most of the lens geometric parameters showed a biphasic behavior, changing rapidly before age 20 years and with a slower linear growth thereafter.
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