Evidence map›Paper›PMID 32293567›Full record

ArticleJMIR public health and surveillance2020

Comparison of Clinical Outcomes of Persons Living With HIV by Enrollment Status in Washington, DC: Evaluation of a Large Longitudinal HIV Cohort Study.

Jenevieve Opoku, Rupali K Doshi, Amanda D Castel, Ian Sorensen, Michael Horberg, Adam Allston, Michael Kharfen, Alan E Greenberg

Open access · goldAbstract read
In one paragraph

Article in JMIR public health and surveillance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jenevieve OpokuHIV/AIDS, Hepatitis, STD, and TB Administration, DC Health, Washington, DC, United States.ORCID 0000-0002-0085-057X
Rupali K DoshiHIV/AIDS, Hepatitis, STD, and TB Administration, DC Health, Washington, DC, United States.ORCID 0000-0002-4799-7907
Amanda D CastelDepartment of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, United States.ORCID 0000-0002-9095-2413
Ian SorensenDepartment of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, United States.ORCID 0000-0002-8598-711X
Michael HorbergKaiser Permanente Medical Group, Rockville, MD, United States.ORCID 0000-0002-6971-7646
Adam AllstonHIV/AIDS, Hepatitis, STD, and TB Administration, DC Health, Washington, DC, United States.ORCID 0000-0003-2465-9849
Michael KharfenHIV/AIDS, Hepatitis, STD, and TB Administration, DC Health, Washington, DC, United States.ORCID 0000-0002-3569-8184
Alan E GreenbergDepartment of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, United States.ORCID 0000-0003-1674-0217
Milken Institute · USGovernment of the District of Columbia · USKaiser Permanente · US

Funding

Terry Beirn CPCRA Clinical Trials UnitUM1AI069503 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI KAN, VIRGINIA · 2012 to 2020
$38.5M
The DC Cohort: A Longitudinal Population-Based Cohort Study of People Living with HIV in Washington, DCR24AI152598 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Amanda Derryck Castel, Marinella Temprosa · 2020 to 2026
$37.9M
CPCRA Clinical Trials UnitU01AI069503 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI GORDIN, FRED M · 2007 to 2011
$33.9M
SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI Italo Mocchetti · 2015 to 2026
$29.6M
NIAID NIH HHS P30 AI117970NIAID NIH HHS R24 AI152598NIAID NIH HHS U01 AI069503NIAID NIH HHS UM1 AI069503
6 · The paper itself

Abstract

backgroundHIV cohort studies have been used to assess health outcomes and inform the care and treatment of people living with HIV disease. However, there may be similarities and differences between cohort participants and the general population from which they are drawn.

objectiveThe objective of this analysis was to compare people living with HIV who have and have not been enrolled in the DC Cohort study and assess whether participants are a representative citywide sample of people living with HIV in the District of Columbia (DC).

methodsData from the DC Health (DCDOH) HIV surveillance system and the DC Cohort study were matched to identify people living with HIV who were DC residents and had consented for the study by the end of 2016. Analysis was performed to identify differences between DC Cohort and noncohort participants by demographics and comorbid conditions. HIV disease stage, receipt of care, and viral suppression were evaluated. Adjusted logistic regression assessed correlates of health outcomes between the two groups.

resultsThere were 12,964 known people living with HIV in DC at the end of 2016, of which 40.1% were DC Cohort participants. Compared with nonparticipants, participants were less likely to be male (68.0% vs 74.9%, P<.001) but more likely to be black (82.3% vs 69.5%, P<.001) and have a heterosexual contact HIV transmission risk (30.3% vs 25.9%, P<.001). DC Cohort participants were also more likely to have ever been diagnosed with stage 3 HIV disease (59.6% vs 47.0%, P<.001), have a CD4 <200 cells/µL in 2017 (6.2% vs 4.6%, P<.001), be retained in any HIV care in 2017 (72.9% vs 59.4%, P<.001), and be virally suppressed in 2017. After adjusting for demographics, DC Cohort participants were significantly more likely to have received care in 2017 (adjusted odds ratio 1.8, 95% CI 1.70-2.00) and to have ever been virally suppressed (adjusted odds ratio 1.3, 95% CI 1.20-1.40).

conclusionsThese data have important implications when assessing the representativeness of patients enrolled in clinic-based cohorts compared with the DC-area general HIV population. As participants continue to enroll in the DC Cohort study, ongoing assessment of representativeness will be required.

Indexed as

Cohort StudiesDistrict of ColumbiaHIV InfectionsHumansLongitudinal StudiesOdds RatioOutcome Assessment, Health CareProgram EvaluationQuality Improvementcohort studiesDC CohortHIVHIV clinical outcomes

Identifiers

PMID32293567
PMCPMC7191350
OpenAlexW2996145332

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.