Evidence map›Paper›PMID 32293452›Full record

ArticleMalaria journal2020

Tools to accelerate falciparum malaria elimination in Cambodia: a meeting report.

Dysoley Lek, James J Callery, Chea Nguon, Mark Debackere, Siv Sovannaroth, Rupam Tripura, Marius Wojnarski, Patrice Piola, Soy Ty Khean, Kylie Manion and 11 more

Open access · goldAbstract read
In one paragraph

Article in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  5. Validation of serological markers of recent exposure toThe Lancet regional health. Western Pacific · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 4 countries.

Dysoley LekCentre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
James J CalleryMahidol-Oxford University Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Chea NguonCentre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Mark DebackereMalaria Consortium, Phnom Penh, Cambodia.
Siv SovannarothCentre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia.
Rupam TripuraMahidol-Oxford University Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Marius WojnarskiArmed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Patrice PiolaInstitut Pasteur du Cambodge, Phnom Penh, Cambodia.
Soy Ty KheanUniversity Research Company Ltd., Phnom Penh, Cambodia.
Kylie ManionMalaria Consortium, Phnom Penh, Cambodia.
Sokomar NguonUniversity Research Company Ltd., Phnom Penh, Cambodia.
Amber KunkelInstitut Pasteur du Cambodge, Phnom Penh, Cambodia.
Lieven VernaeveMalaria Consortium, Phnom Penh, Cambodia.
Thomas J PetoMahidol-Oxford University Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Emily DantzerUniversity of California at San Francisco, San Francisco, USA.
Chan DavoeungProvincial Health Department, Battambang, Cambodia.
William EtienneWorld Health Organization, Phnom Penh, Cambodia.
Arjen M DondorpMahidol-Oxford University Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Luciano TuseoWorld Health Organization, Phnom Penh, Cambodia.
Lorenz von SeidleinMahidol-Oxford University Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand. lorenz@tropmedres.ac.
Jean-Olivier GuintranCentre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia. guintranj@who.int.
Cambodia National Malaria Center · KHMahidol University · THInstitut Pasteur du Cambodge · KHUniversity of Oxford · GBArmed Forces Research Institute of Medical Science · THLondon School of Hygiene & Tropical Medicine · GBMahidol Oxford Tropical Medicine Research Unit · TH

Funding

Medical Research Council MR/T003553/1World Health Organization 001
6 · The paper itself

Abstract

Cambodia targets malaria elimination by 2025. Rapid elimination will depend on successfully identifying and clearing malaria foci linked to forests. Expanding and maintaining universal access to early diagnosis and effective treatment remains the key to malaria control and ultimately malaria elimination in the Greater Mekong Subregion (GMS) in the foreseeable future. Mass Drug Administration (MDA) holds some promise in the rapid reduction of Plasmodium falciparum infections, but requires considerable investment of resources and time to mobilize the target communities. Furthermore, the most practical drug regimen for MDA in the GMS-three rounds of DHA/piperaquine-has lost some of its efficacy. Mass screening and treatment benefits asymptomatic P. falciparum carriers by clearing chronic infections, but in its current form holds little promise for malaria elimination. Hopes that "highly sensitive" diagnostic tests would provide substantial advances in screen and treat programmes have been shown to be misplaced. To reduce the burden on P. falciparum and Plasmodium vivax infections in people working in forested areas novel approaches to the use of malaria prophylaxis in forest workers should be explored. During an October 2019 workshop in Phnom Penh researchers and policymakers reviewed evidence of acceptability, feasibility and effectiveness of interventions to target malaria foci and interrupt P. falciparum transmission and discussed operational requirements and conditions for programmatic implementation.

Indexed as

Diagnostic Tests, RoutineMass Drug AdministrationMass ScreeningAntimalarialsCambodiaDisease EradicationHumansMalaria, FalciparumAntimalarialsCambodiaCase detectionForest malariaMalaria eliminationMass drug administrationPlasmodium falciparumProphylaxisScreening and treatment

Identifiers

PMID32293452
PMCPMC7161105
OpenAlexW3015690750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.