Observational studyRespiratory research2020
Prognostic value of NT-proBNP in patients with severe COVID-19.
Observational study in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04292964 (Prognostic Factors of Patients With COVID-19), which is not on this map. Cited by 169 papers, 21 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognostic Factors of Patients With COVID-19
Who cites it
169 citing papers in PubMed, 21 syntheses or guidelines pooled it.
- Accuracy of routine laboratory tests to predict mortality and deterioration to severe or critical COVID-19 in people with SARS-CoV-2.The Cochrane database of systematic reviews · 2024Pooled it
- Heart failure during the COVID-19 pandemic: clinical, diagnostic, management, and organizational dilemmas.ESC heart failure · 2022Pooled it
- Elevated Natriuretic Peptides in Patients With Severe or Critical COVID-19: A Meta-Analysis.Texas Heart Institute journal · 2022Pooled it
- Cardiac markers of multisystem inflammatory syndrome in children (MIS-C) in COVID-19 patients: A meta-analysis.The American journal of emergency medicine · 2021Pooled it
- Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis.The American journal of emergency medicine · 2021Pooled it
- Predictors of mortality in patients with coronavirus disease 2019: a systematic review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2021Pooled it
- Case fatality rate of COVID-19: a systematic review and meta-analysis.Journal of preventive medicine and hygiene · 2021Pooled it
- Meta-analysis of cardiac markers for predictive factors on severity and mortality of COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- Risk factors for poor outcomes in hospitalised COVID-19 patients: A systematic review and meta-analysis.Journal of global health · 2021Pooled it
- Pooled it
- Can we predict the severe course of COVID-19 - a systematic review and meta-analysis of indicators of clinical outcome?PloS one · 2021Pooled it
- Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID-19 patients: A meta-regression and decision tree analysis.Journal of medical virology · 2020Pooled it
- Does gender influence clinical expression and disease outcomes in COVID-19? A systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Pooled it
- Cardiac manifestations in COVID-19 patients-A systematic review.Journal of cardiac surgery · 2020Pooled it
- Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis.Critical care (London, England) · 2020Pooled it
- Elevated N-terminal pro-brain natriuretic peptide is associated with increased mortality in patients with COVID-19: systematic review and meta-analysis.Postgraduate medical journal · 2020Pooled it
- Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review.PloS one · 2020Pooled it
- Elevated D-Dimer Levels Are Associated With Increased Risk of Mortality in Coronavirus Disease 2019: A Systematic Review and Meta-Analysis.Cardiology in reviewPooled it
109 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundThe outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown.
methodsThe study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records.
resultsThe best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death.
conclusionNT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19.
trial registrationClinicalTrials, NCT04292964. Registered 03 March 2020.
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