ArticleBMC pediatrics2020
Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile.
Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04186949 (Early Origins of Allergy and Asthma), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Origins of Allergy and Asthma
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Natural rubber latex allergy: causes, symptoms, and modern diagnostic methods.Postepy dermatologii i alergologii · 2026Review
- Role of Toll-like Receptors Nine and Ten Polymorphisms in Childhood Bronchial Asthma Control and Their Relation to Cardiac Function.Diagnostics (Basel, Switzerland) · 2025Article
- Maternal influences on offspring food allergy.Immunological reviews · 2024Review
- Efficacy of subcutaneous specific immunotherapy for allergic rhinitis combined with asthma: a retrospective analysis.American journal of translational research · 2024Article
- Association between maternal occupational exposure to cleaning chemicals during pregnancy and childhood wheeze and asthma.Frontiers in epidemiology · 2023Article
- Factors associated with allergy traits around the 2nd year of life: a brazilian cohort study.BMC pediatrics · 2022Article
- Design of an Integrated Clinical Research Informatics System for a Multi-Centre and Multi-Visit Prospective Birth Cohort Study.Studies in health technology and informatics · 2022Article
- Diet Diversity Through the Life-Course as an Opportunity Toward Food Allergy Prevention.Frontiers in allergy · 2021Article
- Forecasting of Atopic Dermatitis in Newborns.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGrowing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000 days (time elapsed from conception to the 2nd birthday). The ARIES birth cohort aims to determine prenatal and perinatal conditions, as well as genetic and epigenetic factors, that participate in the early setting of immune responses, and the role of these in the later determination of the risk of allergic diseases and asthma in the offspring.
methodsWe have designed a birth cohort of 250 families with prenatal recruitment (~ 14 weeks). We will genotype relevant allergy/asthma-associated variants in trios and will perform immunophenotyping and evaluation of allergy biomarkers in cord blood. At 1 and 2 years of age we will assess if infants have developed allergic sensitization, AD, FA, as well as biomarkers of asthma including the asthma predictive index. We will also evaluate how maternal conditions modify immune programming through epigenetic modifications and will then depict newborn epigenetic cues of allergy/asthma risk. Next, we will assess composition/diversity of maternal gut, placenta, breastmilk and infant gut microbiome and their association with immunophenotype and biomarkers at birth, and clinical outcomes at age 1 and 2. Finally, we plan to assess how environmental exposures (perinatal outdoor and indoor pollution, allergens and endotoxin) affect the incidence of allergic sensitization, AD, FA, and risk of asthma. DISCUSSION: The in-depth study of the ARIES birth cohort shall provide crucial information to understand the rising incidence of allergies and asthma in developing countries, and hopefully provide cues on how to prevent and treat these diseases.
trial registrationclinicaltrials.gov NCT04186949, retrospectively registered on December 5, 2019.
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Registered trials
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