ArticleBMC cancer2020
Clinical characteristics and risk factors of 47 cases with ruptured neuroblastoma in children.
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Emergency Surgical Management of Chemotherapy-Induced Tumor Rupture in a Patient with MYCN-Amplified Neuroblastoma: A Case Report.Surgical case reports · 2025Article
- Biallelic inactivation ofGenes & diseases · 2024Article
- A multi-omics approach for biomarker discovery in neuroblastoma: a network-based framework.NPJ systems biology and applications · 2024Article
- [Different concentrations of adapalene induce differentiation and apoptosis of SH-SY5Y cells].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Analysis of the incidence, characteristics, and risk factors of complications during induction chemotherapy in children with high-risk neuroblastoma.European journal of pediatrics · 2024Article
- Article
- Clinical risk factors for patients with ruptured hepatoblastoma in children: a retrospective study from a single center in China.Pediatric surgery international · 2023Article
- Embolization in Pediatric Patients: A Comprehensive Review of Indications, Procedures, and Clinical Outcomes.Journal of clinical medicine · 2022Review
- Prediction for Mitosis-Karyorrhexis Index Status of Pediatric Neuroblastoma via Machine Learning BasedDiagnostics (Basel, Switzerland) · 2022Article
- Impact of 11q Loss of Heterozygosity Status on the Response of High-Risk Neuroblastoma With MYCN Amplification to Neoadjuvant Chemotherapy.Frontiers in pediatrics · 2022Article
- Endovascular approaches in pediatric interventional oncology.CVIR endovascular · 2021Review
- Hemorrhage During Induction Chemotherapy in Neuroblastoma: Additional Risk Factors in High-Risk Patients.Frontiers in pediatrics · 2021Article
- Treatment and outcomes of 1041 pediatric patients with neuroblastoma who received multidisciplinary care in China.Pediatric investigation · 2020Article
- Spontaneous Intrathoracic Rupture of Abdominal Neuroblastoma in a 2-year-old Child: A Rare Case Report.Journal of Indian Association of Pediatric SurgeonsArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuroblastoma (NB) tumor rupture is a rare oncology emergency with a poor prognosis. We aimed to evaluate patient clinical characteristics and risk factors for ruptured NB.
methodsA retrospective study of 47 patients with confirmed NB rupture between January 2009 and January 2019 at Beijing Children's Hospital was conducted. To identify tumor rupture risk factors in high-risk NB patients, we included 93 consecutive non-ruptured high-risk NB patients from January 2017 to January 2019.
resultsThe median age at presentation was 29 months (adrenal and retroperitoneum origin) for 47 ruptured NB patients. Spontaneous tumor rupture occurred in 22 cases; 18 cases occurred during or after the first chemotherapy cycle, and 7 occurred after core needle biopsy. Five patients died of tumor rupture, and 17 patients' parents refused further antitumor therapy. Among the 25 remaining patients, 6 survived without disease, 5 received ongoing treatment and achieved stable disease, and 14 died. According to multivariate logistic regression analysis, a maximum primary tumor diameter > 13.20 cm and MYCN gene amplification were independent risk factors for tumor rupture within high-risk NB.
conclusionsTumor rupture is an uncommon, life-threatening event for NB patients; these patients are most likely to have poor outcomes due to tumor recurrence or rapid progression. Several treatment modalities, including symptomatic support therapy and chemotherapy, are important for saving lives and for developing NB risk-based treatment in the future.
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